2. Apoptosis
  3. Apoptosis
  4. FLQY2

FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations.

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FLQY2

FLQY2 Chemical Structure

CAS No. : 794512-88-2

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FLQY2 Related Antibodies

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Description

FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
78.9 nM
Compound: FL77-20
Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
HCT-116 IC50
40.8 nM
Compound: FL77-20
Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
HeLa IC50
49.5 nM
Compound: FL77-20
Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
HeLa IC50
6.9 nM
Compound: 15 (table 1)
Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
[PMID: 15454230]
HepG2 IC50
86.6 nM
Compound: FL77-20
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
MCF7 IC50
47.1 nM
Compound: FL77-20
Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
[PMID: 38100041]
PC-3 IC50
13.4 nM
Compound: 15 (table 1)
Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
[PMID: 15454230]
Molecular Weight

536.46

Formula

C28H19F3N2O6
CAS No.
SMILES

O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC6=C(OCO6)C=C5C(C7=CC=C(C(F)(F)F)C=C7)=C4CN31
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLQY2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLQY2794512-88-2FLQY 2FLQY-2ApoptosisMia Paca-2pancreatic cancerapoptosisInhibitorinhibitorinhibit

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