FLQY2
FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations.
For research use only. We do not sell to patients.
- CAS No.: 794512-88-2
- Formula: C28H19F3N2O6
- Molecular Weight:536.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
78.9 nM
Compound: FL77-20
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Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human A549 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| HCT-116 | IC50 |
40.8 nM
Compound: FL77-20
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Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HCT-116 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| HeLa | IC50 |
49.5 nM
Compound: FL77-20
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Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HeLa cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| HeLa | IC50 |
6.9 nM
Compound: 15 (table 1)
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Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
Concentration required to inhibit growth of human cervical HeLa carcinoma cell line
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[PMID: 15454230] |
| HepG2 | IC50 |
86.6 nM
Compound: FL77-20
|
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human HepG2 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| MCF7 | IC50 |
47.1 nM
Compound: FL77-20
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Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
Growth inhibition of human MCF7 cells incubated for 48 hrs by MTT reagent based ELISA reader analysis
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[PMID: 38100041] |
| PC-3 | IC50 |
13.4 nM
Compound: 15 (table 1)
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Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
Concentration required to inhibit growth of human prostate PC-3 carcinoma cell line
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[PMID: 15454230] |
Chemical Information
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CAS No. 794512-88-2
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Molecular Weight 536.46
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Formula C28H19F3N2O6
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SMILES
O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC6=C(OCO6)C=C5C(C7=CC=C(C(F)(F)F)C=C7)=C4CN31
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang W, et al. Biological impact and therapeutic potential of a novel camptothecin derivative (FLQY2) in pancreatic cancer through inactivation of the PDK1/AKT/mTOR pathway[J]. Bioorganic Chemistry, 2024, 148: 107436. [Content Brief]
[2]. Wang Y, et al. Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability[J]. Journal of Nanobiotechnology, 2022, 20(1): 402. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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