794512-88-2
794512-88-2
Chemical Structure
FLQY2
- CAS No.: 794512-88-2
- Formula:C28H19F3N2O6
- Molecular Weight:536.46
InChIKey: WLSIGMVEGURPOY-MHZLTWQESA-N
SMILES: O=C1C2=C([C@](CC)(O)C(OC2)=O)C=C3C4=NC5=CC6=C(OCO6)C=C5C(C7=CC=C(C(F)(F)F)C=C7)=C4CN31
Biological Activity: FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations[1][2].
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FLQY2 | FLQY2 is a camptothecin analog that exhibits outstanding antitumor efficacy against various solid tumors. FLQY2 possesses both in vitro and in vivo anti-pancreatic cancer activity, inhibiting cell proliferation, colony formation, inducing apoptosis, and causing cell cycle arrest at nanomolar concentrations. | |||||||||||||||||||||
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References
- [1]. Wang W, et al. Biological impact and therapeutic potential of a novel camptothecin derivative (FLQY2) in pancreatic cancer through inactivation of the PDK1/AKT/mTOR pathway[J]. Bioorganic Chemistry, 2024, 148: 107436. [Content Brief]
- [2]. Wang Y, et al. Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability[J]. Journal of Nanobiotechnology, 2022, 20(1): 402. [Content Brief]
Keywords
