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HDAC-IN-42

HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC₅₀ values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase.

For research use only. We do not sell to patients.

CAS No.: 2454024-18-9
Formula: C₂₀H₁₅NO₇
Molecular Weight:381.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

HDAC-IN-42 Chemical Structure

CAS No.: 2454024-18-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC1

0.19 μM (IC₅₀)

HDAC6

4.98 μM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	6.91 μM Compound: 79a	Antiproliferative activity against human HCT-116 cells Antiproliferative activity against human HCT-116 cells	[PMID: 37875056]
HeLa	IC₅₀	0.23 μM Compound: 42	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 34775332]
HeLa	IC₅₀	6.91 μM Compound: 79a	Antiproliferative activity against human HeLa cells Antiproliferative activity against human HeLa cells	[PMID: 37875056]
HepG2	IC₅₀	6.91 μM Compound: 79a	Antiproliferative activity against human HepG2 cells Antiproliferative activity against human HepG2 cells	[PMID: 37875056]
MCF7	IC₅₀	6.91 μM Compound: 79a	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 37875056]

In Vitro

HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C₅₀s of 9.56, 13.32, 10.46, 6.91 µM for MCF-7, HCT-116, HepG2, Hela cells, respectively^[1].
HDAC-IN-42 (1, 5, 10 µM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells^[1].
HDAC-IN-42 (1, 5, 10 µM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2454024-18-9
Molecular Weight 381.34
Formula C₂₀H₁₅NO₇
SMILES

O=C(C1=CC2=CC=C(OC)C=C2OC1=O)OC3=CC=CC(/C=C/C(NO)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ding J, et al. Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities. Bioorg Chem. 2020 Aug;101:104023. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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