2454024-18-9
2454024-18-9
Chemical Structure
HDAC-IN-42
- CAS No.: 2454024-18-9
- Formula:C20H15NO7
- Molecular Weight:381.34
IUPAC Name: (E)-3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate
InChIKey: KZJPZOCQYVSTEC-VMPITWQZSA-N
SMILES: O=C(C1=CC2=CC=C(OC)C=C2OC1=O)OC3=CC=CC(/C=C/C(NO)=O)=C3
Biological Activity: HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1].
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HDAC-IN-42 | HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase. | |||||||||||||||||||||
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References
Keywords
