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Cat. No.: HY-171184

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EAPB0503

EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC₅₀=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein .

For research use only. We do not sell to patients.

CAS No.: 1140627-77-5
Formula: C₁₈H₁₆N₄O
Molecular Weight:304.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

EAPB0503 Chemical Structure

CAS No.: 1140627-77-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All PARP Isoforms :

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	IC₅₀	185 nM Compound: EAPB0503	Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]
A-375	IC₅₀	0.2 μM Compound: 7b, EAPB0503	Cytotoxicity against human A375 cells after 96 hrs by MTT assay Cytotoxicity against human A375 cells after 96 hrs by MTT assay	[PMID: 19278757]
A-375	IC₅₀	0.2 μM Compound: EAPB0503	Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay	[PMID: 27094151]
A-375	IC₅₀	383 nM Compound: EAPB0503	Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]
IPC-298	IC₅₀	469 nM Compound: EAPB0503	Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human IPC-298 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]
MeWo	IC₅₀	125 nM Compound: EAPB0503	Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Antiproliferative activity against human MeWo cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 33309473]

Chemical Information

CAS No. 1140627-77-5
Molecular Weight 304.35
Formula C₁₈H₁₆N₄O
SMILES

COC1=CC(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sonia Khier, et al. Quantitation of imidazo[1,2-a]quinoxaline derivatives in human and rat plasma using LC/ESI-MS. J. Sep. Sci. 2009, 32, 1363-1373.

[2]. Jessica Saliba, et al. EAPB0503, a novel imidazoquinoxaline derivative, inhibits growth and induces apoptosis in chronic myeloid leukemia cells. Anticancer Drugs. 2014 Jul;25(6):624-32. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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EAPB0503

All PARP Isoforms

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EAPB0503 Related Classifications

HY-171184 Related Classifications