1140627-77-5
Chemical Structure
EAPB0503
- CAS No.: 1140627-77-5
- Formula:C18H16N4O
- Molecular Weight:304.35
InChIKey: PLJRXCRNKAGLBD-UHFFFAOYSA-N
SMILES: COC1=CC(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)=CC=C1
Biological Activity: EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein [1] [2].
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EAPB0503 | EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein . | |||||||||||||||||||||
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- [1]. Sonia Khier, et al. Quantitation of imidazo[1,2-a]quinoxaline derivatives in human and rat plasma using LC/ESI-MS. J. Sep. Sci. 2009, 32, 1363-1373.
- [2]. Jessica Saliba, et al. EAPB0503, a novel imidazoquinoxaline derivative, inhibits growth and induces apoptosis in chronic myeloid leukemia cells. Anticancer Drugs. 2014 Jul;25(6):624-32. [Content Brief]
Keywords
