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Cat. No.: HY-139828

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Anticancer agent 14

Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2762698-14-4
Formula: C₂₉H₃₄N₂O₃
Molecular Weight:458.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 14 Chemical Structure

CAS No.: 2762698-14-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

Cellular Effect

Cell Line	Type	Value	Description	References
LA7	IC₅₀	0.19 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
LA7	IC₅₀	0.24 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
LA7	IC₅₀	0.66 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF-10A	IC₅₀	>18 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
MCF-10A	IC₅₀	>25 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.2 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.25 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.3 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.65 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.7 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.7 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]

Chemical Information

CAS No. 2762698-14-4
Molecular Weight 458.59
Formula C₂₉H₃₄N₂O₃
SMILES

COC(C=C1)=CC=C1C[C@H]2COC3=CC=CC=C3N2CC4=CC=C(OCCN5CCCC5)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jana AK, et al. Tyrosine-Derived Novel Benzoxazine Active in a Rat Syngenic Mammary Tumor Model of Breast Cancer. J Med Chem. 2021 Nov 11;64(21):16293-16316. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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