PARP1/BRD4-IN-3
PARP1/BRD4-IN-3 (compound HF4) is a potent BRD4 and PARP1 inhibitor with IC50 values of 1210, 2019 nM for BRD4, PARP1, respectively. PARP1/BRD4-IN-3 shows antiproliferative activities. PARP1/BRD4-IN-3 induces apoptosis and cell cycle arrest at G0/G1 phase. PARP1/BRD4-IN-3 causes DNA damage and reduces the protein expression of Rad51. PARP1/BRD4-IN-3 shows antitumor efficacy.
For research use only. We do not sell to patients.
- Formula: C18H17FN2O3S
- Molecular Weight:360.40
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
|
PARP1 2019 nM (IC50) |
BRD4 1210 nM (IC50) |
BRD2 BD2 6831 nM (IC50) |
BRD3 4792 nM (IC50) |
BRD4 BD1 204 nM (IC50) |
BRD4 BD2 801 nM (IC50) |
BRD1 55618 nM (IC50) |
Chemical Information
-
Molecular Weight 360.40
-
Formula C18H17FN2O3S
-
SMILES
O=S(C1=CC=C(F)C(C)=C1)(NC2=CC3=C(NC(C(CC)=C3)=O)C=C2)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP1/BRD4-IN-3 Related Classifications
HY-169170 Related Classifications
Powered by Bioz