2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 15

Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation.

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Apoptosis inducer 15

Apoptosis inducer 15 Chemical Structure

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Apoptosis inducer 15 Related Antibodies

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Description

Apoptosis inducer 15 (Compound 3) induces cell apoptosis and cell cycle arrest at G2/M phase. Apoptosis inducer 15 is cytotoxicitic without causing DNA fragmentation[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.2 μM
Compound: 3
Antiproliferative activity against human A549 cells by MTT colorimetric assay
Antiproliferative activity against human A549 cells by MTT colorimetric assay
[PMID: 38527380]
HL-60 IC50
2.07 μM
Compound: 3
Antiproliferative activity against human HL-60 cells by MTT colorimetric assay
Antiproliferative activity against human HL-60 cells by MTT colorimetric assay
[PMID: 38527380]
HeLa IC50
0.11 μM
Compound: 3
Antiproliferative activity against human HeLa cells by MTT colorimetric assay
Antiproliferative activity against human HeLa cells by MTT colorimetric assay
[PMID: 38527380]
Jurkat IC50
1.01 μM
Compound: 3
Antiproliferative activity against human Jurkat cells by MTT colorimetric assay
Antiproliferative activity against human Jurkat cells by MTT colorimetric assay
[PMID: 38527380]
K562 IC50
0.03 μM
Compound: 3
Antiproliferative activity against human K562 cells by MTT colorimetric assay
Antiproliferative activity against human K562 cells by MTT colorimetric assay
[PMID: 38527380]
MCF7 IC50
3.38 μM
Compound: 3
Antiproliferative activity against human MCF7 cells by MTT colorimetric assay
Antiproliferative activity against human MCF7 cells by MTT colorimetric assay
[PMID: 38527380]
MDA-MB-231 IC50
2.88 μM
Compound: 3
Antiproliferative activity against human MDA-MB-231 cells by MTT colorimetric assay
Antiproliferative activity against human MDA-MB-231 cells by MTT colorimetric assay
[PMID: 38527380]
MRC5 IC50
> 100 μM
Compound: 3
Antiproliferative activity against human MRC5 cells by MTT colorimetric assay
Antiproliferative activity against human MRC5 cells by MTT colorimetric assay
[PMID: 38527380]
Raji IC50
5.97 μM
Compound: 3
Antiproliferative activity against human Raji cells by MTT colorimetric assay
Antiproliferative activity against human Raji cells by MTT colorimetric assay
[PMID: 38527380]
In Vitro

Apoptosis inducer 15 inhibits proliferations of cancer cells K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB-231 and HeLa, with IC50s from 0.03-5.97 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 15 Related Antibodies
Molecular Weight

256.27

Formula

C11H12O5S
SMILES

O=C1C[C@H]2O[C@@H]([C@@H]([C@H]2O1)O)[C@@H](C3=CC=CS3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptosis inducer 15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 15Apoptosis inducer15Apoptosis inducer-15ApoptosisK562HL-60JurkatRajiMCF-7MDA-MB-231HeLaInhibitorinhibitorinhibit

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