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Cat. No.: HY-170992

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Autophagy agonist-1

Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC₅₀s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells.

For research use only. We do not sell to patients.

Formula: C₃₃H₄₁N₃O₅
Molecular Weight:559.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Autophagy agonist-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Hot Topics (2)
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CDK4

All CDK Isoforms :

Chemical Information

Molecular Weight 559.70
Formula C₃₃H₄₁N₃O₅
SMILES

O=C1C2[C@@]3([H])[C@@](C3(C)C)([H])C[C@@H](C)[C@@](C=C(C)[C@@H]4OCC5=NN=C(/C=C/C6=CC=C(N(C)C)C=C6)O5)1[C@]4(O)[C@H](O)C(C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu Z, et al. 20-Deoxyingenol ester and ether derivatives: Synthesis, properties and cytotoxicity. Bioorg Chem. 2025 Mar;156:108207. [Content Brief]

Hot Topics

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Topics Mitophagy: A Central Target in Neurodegenerative Diseases
Mitophagy is a selective form of autophagy that eliminates damaged or dysfunctional mitochondria and thereby preserves mitochondrial quality control, cellular homeostasis, and neuronal survival.

2026-06-18
Topics When Mitophagy Becomes An Innate Immune Checkpoint
Mitophagy becomes an innate immune checkpoint when selective autophagic removal of damaged mitochondria regulates the availability of mitochondrial danger signals that activate innate immune pathways.

2026-06-18

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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