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Cat. No.: HY-149252

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Tubulin inhibitor 32

Name: Tubulin inhibitor 32
Brand: MedChemExpress
SKU: HY-149252
Price: 545.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 2923531-39-7
Formula: C₁₈H₁₉N₃O₃
Molecular Weight:325.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Tubulin inhibitor 32 Chemical Structure

CAS No.: 2923531-39-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	2.65 μM Compound: 6y	Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HEK-293T	IC₅₀	>80 μM Compound: 6y	Antiproliferative activity against human HEK293T cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HEK293T cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HeLa	IC₅₀	24.61 μM Compound: 6y	Antiproliferative activity against human HeLa cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
HepG2	IC₅₀	1.54 μM Compound: 6y	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
MDA-MB-231	IC₅₀	11.41 μM Compound: 6y	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]
SW480	IC₅₀	37.53 μM Compound: 6y	Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK-8 assay	[PMID: 36940610]

In Vitro

Tubulin inhibitor 32 (compound 6y) (0-2 µM; 24 h) suppresses the formation of colonies in a dose-dependent manner in HCT-116 cells^[1].
Tubulin inhibitor 32 (0-100 µM; 24 h) inhibits microtubule polymerization with an IC₅₀ of 8.4 µM^[1].
Tubulin inhibitor 32 (0-2 µM; 24, 48 h) induces apoptosis and cell cycle arrest at G2/M phase^[1].
Tubulin inhibitor 32 shows metabolic stability with T_1/2 values of 106.2, 6.9 min in human liver microsomes and Rat liver microsomes, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HepG2, SW480, Hela, MDA-MB-231 cells
Concentration:

0-64 µM
Incubation Time:

48 h
Result:

Showed anti-proliferative activity with IC₅₀s of 1.54, 37.53, 24.61, 11.41 µM for HepG2, SW480, Hela, MDA-MB-231 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

0, 0.5, 1, 2 µM
Incubation Time:

48 h
Result:

Caused cell cycle arrest in G2/M phase in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

0, 0.125, 0.5, 2 µM
Incubation Time:

24 h
Result:

Induced cell apoptosis in a dose dependent manner.

In Vivo

Tubulin inhibitor 32 (50, 100 mg/kg; p.o.; daily for 20 days) shows anti-tumor activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4-6 weeks old male nude mice (HCT-116 tumor model)^[1]
Dosage:

50, 100 mg/kg
Administration:

P.o.; daily for 20 days
Result:

Decreased the tumor volume and tumor weight by 44.1% and 27.0% at the dose of 50 mg/kg, respectively

Chemical Information

CAS No. 2923531-39-7
Molecular Weight 325.36
Formula C₁₈H₁₉N₃O₃
SMILES

COC1=CC(C2=CC=NN2C3=CC=C(C=C3)N)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li G, et al. Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities. Eur J Med Chem. 2023 Apr 5;252:115284. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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