2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. Tubulin inhibitor 32

Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity.

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Tubulin inhibitor 32 Chemical Structure

Tubulin inhibitor 32 Chemical Structure

CAS No. : 2923531-39-7

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Tubulin inhibitor 32 Related Antibodies

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Description

Tubulin inhibitor 32 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 32 shows anti-proliferative activity and inhibits microtubule polymerization. Tubulin inhibitor 32 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin inhibitor 32 shows anti-tumor activity[1].

In Vitro

Tubulin inhibitor 32 (compound 6y) (0-2 µM; 24 h) suppresses the formation of colonies in a dose-dependent manner in HCT-116 cells[1].
Tubulin inhibitor 32 (0-100 µM; 24 h) inhibits microtubule polymerization with an IC50 of 8.4 µM[1].
Tubulin inhibitor 32 (0-2 µM; 24, 48 h) induces apoptosis and cell cycle arrest at G2/M phase[1].
Tubulin inhibitor 32 shows metabolic stability with T1/2 values of 106.2, 6.9 min in human liver microsomes and Rat liver microsomes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 32 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HepG2, SW480, Hela, MDA-MB-231 cells
Concentration: 0-64 µM
Incubation Time: 48 h
Result: Showed anti-proliferative activity with IC50s of 1.54, 37.53, 24.61, 11.41 µM for HepG2, SW480, Hela, MDA-MB-231 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0, 0.5, 1, 2 µM
Incubation Time: 48 h
Result: Caused cell cycle arrest in G2/M phase in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0, 0.125, 0.5, 2 µM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose dependent manner.
In Vivo

Tubulin inhibitor 32 (50, 100 mg/kg; p.o.; daily for 20 days) shows anti-tumor activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks old male nude mice (HCT-116 tumor model)[1]
Dosage: 50, 100 mg/kg
Administration: P.o.; daily for 20 days
Result: Decreased the tumor volume and tumor weight by 44.1% and 27.0% at the dose of 50 mg/kg, respectively
Molecular Weight

325.36

Formula

C18H19N3O3
CAS No.
SMILES

COC1=CC(C2=CC=NN2C3=CC=C(C=C3)N)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 322923531-39-7Tubulin inhibitor32Tubulin inhibitor-32ApoptosisMicrotubule/Tubulinanti-proliferativemicrotubule polymerizationapoptosisG2/Manti-tumororally activeInhibitorinhibitorinhibit

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