Tubulin polymerization-IN-9
Tubulin polymerization-IN-9 is a potent tubulin inhibitor with IC50 of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities.
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- CAS No.: 2485020-93-5
- Formula: C19H19NO5Se
- Molecular Weight:420.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.82 μM (tubulin)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | IC50 |
0.621 μM
Compound: 11k
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Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32853870] |
| HepG2 | IC50 |
0.525 μM
Compound: 11k
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32853870] |
| K562 | IC50 |
0.287 μM
Compound: 11k
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 32853870] |
Tubulin polymerization-IN-9 (compound 11k) (0.1, 1, 10 μM; 72 hours) has potent activity against these three cancer cell lines with IC50 values ranging from 0.287 to 0.621 μM[1].
Tubulin polymerization-IN-9 (0.15, 0.3 and 0.6 μM; 24 hours) induces a dose-dependent collapse of the microtubule networks[1].
Tubulin polymerization-IN-9 (0.15, 0.3 and 0.6 μM; 48 hours) observes a gradual accumulation of cells at G2/M phase in K562 cells[1].
Tubulin polymerization-IN-9 (0.15, 0.3 and 0.6 μM; 72 hours) effectively induces cell apoptosis in K562 cells in a concentration-dependent manner[1].
Tubulin polymerization-IN-9 (0.15, 0.3 and 0.6 μM; 24 hours) causes mitochondrial depolarization of K562 cells in the process of apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 HepG2 and HCT-8 cells[1]
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Concentration:0.1, 1, 10 μM
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Incubation Time:72 hours
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Result:Showed potent activity against these three cancer cell lines with IC50 values ranging from 0.287 to 0.621 μM.
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Cell Line:K562 cells[1]
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Concentration:0.15, 0.3 and 0.6 μM
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Incubation Time:24 hours
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Result:Induced a dose-dependent collapse of the microtubule networks.
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Cell Line:K562 cells[1]
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Concentration:0.15, 0.3 and 0.6 μM
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Incubation Time:48 hours
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Result:Observed a gradual accumulation of cells at G2/M phase in K562 cells.
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Cell Line:K562 cells[1]
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Concentration:0.15, 0.3 and 0.6 μM
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Incubation Time:72 hours
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Result:Effectively induced cell apoptosis in K562 cells in a concentration-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice (5 weeks; injected with H22 cells; n=6)[1]
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Dosage:15 and 30 mg/kg
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Administration:IV; once a day, for 21 days
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Result:Effectively suppressed the tumor volume and reduced tumor weight by 71.1% at a dose of 30 mg/kg.
Chemical Information
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CAS No. 2485020-93-5
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Molecular Weight 420.32
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Formula C19H19NO5Se
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SMILES
COC1=CC([Se](=O)(/C=C/C2=CC=CC3=C2C=CN3)=O)=CC(OC)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-9 Related Classifications
HY-146718 Related Classifications
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