2485020-93-5
2485020-93-5
Chemical Structure
Tubulin polymerization-IN-9
- CAS 番号: 2485020-93-5
- Formula:C19H19NO5Se
- Molecular Weight:420.32
IUPAC Name: (E)-4-(2-((3,4,5-trimethoxyphenyl)selenonyl)vinyl)-1H-indole
InChIKey: XYWOAVZREMLXJO-CSKARUKUSA-N
SMILES: COC1=CC([Se](=O)(/C=C/C2=CC=CC3=C2C=CN3)=O)=CC(OC)=C1OC
Biological Activity: Tubulin polymerization-IN-9 is a potent tubulin inhibitor with IC50 of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities[1].
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Tubulin polymerization-IN-9 | Tubulin polymerization-IN-9 is a potent tubulin inhibitor with IC50 of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities. | |||||||||||||||||||||
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References
Keywords
