STAT3-IN-20

Cat. No.: HY-155982 Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

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STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC₅₀: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC₅₀: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis.

For research use only. We do not sell to patients.

STAT3-IN-20 Chemical Structure

CAS No. : 2768427-54-7

Size Price Stock Quantity

1 mg USD 210 In-stock

Estimated Time of Arrival: December 31

5 mg USD 580 In-stock

Estimated Time of Arrival: December 31

10 mg USD 950 In-stock

Estimated Time of Arrival: December 31

25 mg USD 1710 In-stock

Estimated Time of Arrival: December 31

50 mg USD 2223 In-stock

Estimated Time of Arrival: December 31

100 mg USD 2890 In-stock

Estimated Time of Arrival: December 31

200 mg Get quote

500 mg Get quote

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Based on 1 publication(s) in Google Scholar

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Description

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC₅₀: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC₅₀: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis^[1].

IC₅₀ & Target
0.65 μM (STAT3)^[1]

Molecular Weight
593.64

Formula
C₃₀H₂₇F₄N₇S

CAS No.
2768427-54-7

Appearance

Solid

Color

Light yellow to yellow

SMILES
FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility
In Vitro:

DMSO : 100 mg/mL (168.45 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 1.6845 mL 8.4226 mL 16.8452 mL

5 mM 0.3369 mL 1.6845 mL 3.3690 mL

10 mM 0.1685 mL 0.8423 mL 1.6845 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Purity & Documentation

Purity: 99.83%
Select Batch:

Data Sheet (274 KB) SDS (0 KB)
COA (253 KB) HNMR (142 KB) RP-HPLC (138 KB) LCMS (107 KB)
Handling Instructions (2659 KB)

References

[1]. Wang R, et al. Discovery, Optimization, and Evaluation of Novel N-(Benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18. [Content Brief]

[1]. Wang R, et al. Discovery, Optimization, and Evaluation of Novel N-(Benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 1.6845 mL 8.4226 mL 16.8452 mL 42.1131 mL

5 mM 0.3369 mL 1.6845 mL 3.3690 mL 8.4226 mL

10 mM 0.1685 mL 0.8423 mL 1.6845 mL 4.2113 mL

15 mM 0.1123 mL 0.5615 mL 1.1230 mL 2.8075 mL

20 mM 0.0842 mL 0.4211 mL 0.8423 mL 2.1057 mL

25 mM 0.0674 mL 0.3369 mL 0.6738 mL 1.6845 mL

30 mM 0.0562 mL 0.2808 mL 0.5615 mL 1.4038 mL

40 mM 0.0421 mL 0.2106 mL 0.4211 mL 1.0528 mL

50 mM 0.0337 mL 0.1685 mL 0.3369 mL 0.8423 mL

60 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7019 mL

80 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5264 mL

100 mM 0.0168 mL 0.0842 mL 0.1685 mL 0.4211 mL

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STAT3-IN-20 Related Classifications

JAK/STAT Signaling Stem Cell/Wnt

STAT

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-202768427-54-7STATSTAT3 phosphorylationDU145MDA-MB-231cancerantiproliferativeInhibitorinhibitorinhibit

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Size	Price	Stock	Quantity
1 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1710	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2223	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2890	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

DMSO	1 mM	1.6845 mL	8.4226 mL	16.8452 mL	42.1131 mL
	5 mM	0.3369 mL	1.6845 mL	3.3690 mL	8.4226 mL
	10 mM	0.1685 mL	0.8423 mL	1.6845 mL	4.2113 mL
	15 mM	0.1123 mL	0.5615 mL	1.1230 mL	2.8075 mL
	20 mM	0.0842 mL	0.4211 mL	0.8423 mL	2.1057 mL
	25 mM	0.0674 mL	0.3369 mL	0.6738 mL	1.6845 mL
	30 mM	0.0562 mL	0.2808 mL	0.5615 mL	1.4038 mL
	40 mM	0.0421 mL	0.2106 mL	0.4211 mL	1.0528 mL
	50 mM	0.0337 mL	0.1685 mL	0.3369 mL	0.8423 mL
	60 mM	0.0281 mL	0.1404 mL	0.2808 mL	0.7019 mL
	80 mM	0.0211 mL	0.1053 mL	0.2106 mL	0.5264 mL
	100 mM	0.0168 mL	0.0842 mL	0.1685 mL	0.4211 mL

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STAT3-IN-20

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STAT3-IN-20 Related Antibodies

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Complete Stock Solution Preparation Table

STAT3-IN-20 Related Classifications

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