EGFR-IN-192
EGFR-IN-192 is an anticancer agent. EGFR-IN-192 inhibits EGFR (IC50: 0.12 μM), downregulates the HIF-VEGF and PI3K/AKT/mTOR pathways, upregulates the tumor suppressor gene PTEN, and induces cell cycle arrest and apoptosis in tumor cells. EGFR-IN-192 exhibits antitumor activity and can be used in tumor research.
For research use only. We do not sell to patients.
- Formula: C31H24N6O3
- Molecular Weight:528.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
EGFR-IN-192 (Compound 7) potently inhibits the proliferation of PC-3, HePG-2 and MCF-7 cancer cells with IC50 values of 15.54 μM, 8.22 μM and 5.53 μM, respectively, and exhibits selectivity towards cancer cells compared to normal WI-38 fibroblasts[1].
EGFR-IN-192 (48 h) induces G2/M cell cycle arrest and apoptosis in MCF-7 cells[1].
EGFR-IN-192 (5.53 μM; 48 h) downregulates the gene expressions of HIF-1α and VEGF in MCF-7 cells[1].
EGFR-IN-192 (48 h) regulates the PI3K/AKT/mTOR pathway in MCF-7 cells by downregulating PI3K, AKT and mTOR, and upregulating PTEN[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7
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Concentration:5.53 μM
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Incubation Time:48 h
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Result:Significantly downregulated HIF-1α and VEGF mRNA expression compared to untreated cells.
Chemical Information
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Molecular Weight 528.56
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Formula C31H24N6O3
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SMILES
O=C(N1)C(O)=C(NC(CN2)=NC3=C2C=CC=C3)C(C1=N4)=C(C5=CC=C(N(C)C)C=C5)C6=C4C7=CC=CC=C7C6=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-192 Related Classifications
HY-181097 Related Classifications
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Keywords
- EGFR-IN-192
- Apoptosis
- EGFR
- VEGFR
- mTOR
- HIF/HIF Prolyl-Hydroxylase
- PI3K
- Akt
- PTEN
- Epidermal growth factor receptor
- ErbB-1
- HER1
- Vascular endothelial growth factor receptor
- Mammalian target of Rapamycin
- Hypoxia-inducible factors
- HIFs
- HIF-PH
- Phosphoinositide 3-kinase
- PKB
- Protein kinase B
- Phosphatase and tensin homolog
- MMAC1
- MCF-7
- G2/M cell-cycle arrest
- HIF-1α
- breast cancer
- VEGF
- Inhibitor
- inhibitor
- inhibit