FLT3-ITD-IN-3
FLT3-ITD-IN-3 (13v), an orally active FLT3-ITD (FLT3 internal tandem duplication) inhibitor, disrupts FLT3 signal transduction and induced G0/G1 cell cycle arrest and apoptosis. FLT3-ITD-IN-3 (13v) is used in the research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 3018150-80-3
- Formula: C27H21ClF2N6O5
- Molecular Weight:582.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FLT3-ITD-IN-3 (13v) potently and selectively inhibits the proliferation of the three FLT3-ITD bearing cell lines MOLM-14, MOLM-13, and MV4-11, with IC50 values of 0.59, 0.14 and 0.41 μM, respectively[1].
FLT3-ITD-IN-3 (13v) strongly suppresses the phosphorylation of FLT3 and STAT5 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3018150-80-3
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Molecular Weight 582.94
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Formula C27H21ClF2N6O5
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SMILES
O=C(C(C(C)=C1)=NN(C2=CC(Cl)=CC=C2F)C1=O)NC3=CC=C(OC4=CC(NC(N5CC(O)C5)=O)=NC=C4)C(F)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FLT3-ITD-IN-3 Related Classifications
HY-173214 Related Classifications
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