FLT3-ITD-IN-3
FLT3-ITD-IN-3 (13v), an orally active FLT3-ITD (FLT3 internal tandem duplication) inhibitor, disrupts FLT3 signal transduction and induced G0/G1 cell cycle arrest and apoptosis. FLT3-ITD-IN-3 (13v) is used in the research of acute myeloid leukemia (AML).
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- CAS No.: 3018150-80-3
- Formule: C27H21ClF2N6O5
- Masse moléculaire:582.94
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
FLT3-ITD-IN-3 (13v) potently and selectively inhibits the proliferation of the three FLT3-ITD bearing cell lines MOLM-14, MOLM-13, and MV4-11, with IC50 values of 0.59, 0.14 and 0.41 μM, respectively[1].
FLT3-ITD-IN-3 (13v) strongly suppresses the phosphorylation of FLT3 and STAT5 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3018150-80-3
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Masse moléculaire 582.94
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Formule C27H21ClF2N6O5
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SMILES
O=C(C(C(C)=C1)=NN(C2=CC(Cl)=CC=C2F)C1=O)NC3=CC=C(OC4=CC(NC(N5CC(O)C5)=O)=NC=C4)C(F)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FLT3-ITD-IN-3 Related Classifications
HY-173214 Related Classifications
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