Pelargonidin chloride
Based on 1 publication(s) in Google Scholar
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment.
For research use only. We do not sell to patients.
- Purity: 98.52%
- CAS No.: 134-04-3
- Formula: C15H11ClO5
- Molecular Weight:306.70
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Pelargonidin chloride
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Biological Activity
Pelargonidin chloride (10-100 µM; 1, 3, 5 days) inhibits cell viability in a time- and dose-dependent manner in JB6 P+ cells[2].
Pelargonidin chloride (10, 30, 50 µM; 3 days) induces cell cycle arrest at sub-G1 phase in a dose-dependent manner[2].
Pelargonidin chloride (0,10, 30, 50 µM; 5 days) increases the mRNA and protein expression of HO-1, NQO1, Nrf2 in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:JB6 P+ cells
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Concentration:10, 30, 50, 70, 100 μM
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Incubation Time:1, 3, 5 days
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Result:Showed cytotoxicity in a time- and dose-dependent manner.
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Cell Line:JB6 P+ cells
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Concentration:10, 30, 50 µM
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Incubation Time:3 days
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Result:Induced cell cycle arrest at sub-G1 phase in a dose-dependent manner.
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Cell Line:JB6 P+ cells
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Concentration:0,10, 30, 50 µM
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Incubation Time:6h, 5 days
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Result:Promoted the mRNA expression of HO-1 and NQO1 after 6 hours and 5 days.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:250-300 g, 12 weeks Wistar rats (Aβ 25-35 (1 µg/µL for 5 μL, injectes bilaterally into the hippocampi)[3]
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Dosage:3 mg/kg
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Administration:IP; once
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Result:Significant decreased in escape latency and traveled distance in comparison to the Aβ-treated group, increased the antioxidant power of hippocampus homogenate.
Chemical Information
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CAS No. 134-04-3
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Appearance Solid
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Molecular Weight 306.70
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Formula C15H11ClO5
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Color Brown to reddish brown
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SMILES
OC1=CC=C(C2=C(O)C=C3C(C=C(O)C=C3O)=[O+]2)C=C1.[Cl-]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 May 31:489:144992. PMID: 40466530
Solvent & Solubility
DMSO : 50 mg/mL (163.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. S A van Acke, et al. Flavonoids as Scavengers of Nitric Oxide Radical.Biochem Biophys Res Commun. 1995 Sep 25;214(3):755-9. [Content Brief]
[2]. Soleimani Asl S, et al. Pelargonidin exhibits restoring effects against amyloid β-induced deficits in the hippocampus of male rats. Med J Islam Repub Iran. 2019 Dec 12;33:135. [Content Brief]
[3]. Li S, et al. Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation. Chem Biol Interact. 2019 Aug 25;309:108701. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2605 mL | 16.3026 mL | 32.6052 mL | 81.5129 mL |
| 5 mM | 0.6521 mL | 3.2605 mL | 6.5210 mL | 16.3026 mL | |
| 10 mM | 0.3261 mL | 1.6303 mL | 3.2605 mL | 8.1513 mL | |
| 15 mM | 0.2174 mL | 1.0868 mL | 2.1737 mL | 5.4342 mL | |
| 20 mM | 0.1630 mL | 0.8151 mL | 1.6303 mL | 4.0756 mL | |
| 25 mM | 0.1304 mL | 0.6521 mL | 1.3042 mL | 3.2605 mL | |
| 30 mM | 0.1087 mL | 0.5434 mL | 1.0868 mL | 2.7171 mL | |
| 40 mM | 0.0815 mL | 0.4076 mL | 0.8151 mL | 2.0378 mL | |
| 50 mM | 0.0652 mL | 0.3261 mL | 0.6521 mL | 1.6303 mL | |
| 60 mM | 0.0543 mL | 0.2717 mL | 0.5434 mL | 1.3585 mL | |
| 80 mM | 0.0408 mL | 0.2038 mL | 0.4076 mL | 1.0189 mL | |
| 100 mM | 0.0326 mL | 0.1630 mL | 0.3261 mL | 0.8151 mL |
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