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Cat. No.: HY-175520

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SHP2-IN-42

SHP2-IN-42 is a src homology 2 domain-containing phosphatase 2 (SHP2) inhibitor with an IC₅₀ of 15 nM. SHP2-IN-42 inhibits cell proliferation and induces apoptosis and G1 phase cell cycle arrest. SHP2-IN-42 can be used for the research of cancer, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

Formula: C₂₇H₃₀N₆O₄
Molecular Weight:502.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SHP2-IN-42 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

SHP2

15 nM (IC₅₀)

In Vitro

SHP2-IN-42 (Compound B8) inhibits cell proliferation with IC₅₀ values of 4.96 μM in MV4-11 cells and 4.25 μM in MOLM-13 cells^[1].
SHP2-IN-42 (2.5-10 μM, 48 h) induces apoptosis in MOLM-13 cells^[1].
SHP2-IN-42 (2.5-10 μM, 24 h) induces G1 phase cell cycle arrest in MOLM-13 cells^[1].
SHP2-IN-42 (2.5-10 μM, 3 h) reduces ERK phosphorylation levels in MOLM-13 cells^[1].
SHP2-IN-42 (3-6 μM, 24 h) induces mitochondrial membrane potential collapse and activation of apoptosis companied with MCL-1 inhibitor VU661013 (HY-112859) in MOLM-13 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MOLM-13 cells
Concentration:

2.5, 5 and 10 μM
Incubation Time:

3 h
Result:

Reduced ERK phosphorylation (p-ERK).

Parmacokinetics

Species	Dose	Route	C_max	T_1/2	MRT	V_d	CL	AUC_0-t	T_max	F
Rat^[1]	0.5 mg/kg	i.v.	3629 ng/mL	2.56 h	1.07 h	1.52 L/kg	6.54 mL/min/kg	1314 ng·h/mL	/	/
Rat^[1]	10 mg/kg	p.o.	524 ng/mL	4.16 h	5.89 h	/	/	4410 L/kg	1.67 h	16.8 %

Chemical Information

Molecular Weight 502.56
Formula C₂₇H₃₀N₆O₄
SMILES

C[C@@H]1OCC2([C@@H]1N)CCN(CC2)C3=NN4C=CC(C5=CC=C(C=C5)N6C=CC=C6C(O)=O)=C4C(N3C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang M, et al. Structure-guided expansion strategy unveils potent allosteric SHP2 inhibitors with synergistic efficacy against AML through MCL-1 co-targeting. Eur J Med Chem. 2025 Nov 15;298:117988. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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