1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. Src
    Bcr-Abl
    Apoptosis
  3. AZD0424

AZD0424 

Cat. No.: HY-112314
Handling Instructions

AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells.

For research use only. We do not sell to patients.

AZD0424 Chemical Structure

AZD0424 Chemical Structure

CAS No. : 692054-06-1

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Description

AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2].

IC50 & Target

Src/Abl kinase inhibitor (SrcK-I), apoptosis[1]

In Vitro

AZD0424 (1-5 μM; 24-48 hours) is emerged to be the more effective of the three tested inhibitors (AZM559756, AZD0530 and AZD0424), inducing the highest levels of apoptosis with the lowest concentrations in lymphoma cells[2].
AZD0424 (5 μM; 48 hours) leads to increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells, whereas the cell cycle progression of the nonsensitive cell lines Raji and Jurkat remains unaffected[2].

Apoptosis Analysis[2]

Cell Line: DOHH-2, WSU-NHL, Raji, Jurkat, Karpas-299 and HUT78 cells
Concentration: 1 μM; 2 μM; 3 μM; 4 μM; 5 μM;
Incubation Time: 24 hours, 48 hours
Result: Induced apoptosis in lymphoma cells.

Cell Cycle Analysis[2]

Cell Line: DOHH-2, WSU-NHL, Raji and Jurkat cells
Concentration: 1 μM; 2 μM; 3 μM; 4 μM; 5 μM;
Incubation Time: 48 hours
Result: Increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells.
Molecular Weight

528.99

Formula

C₂₅H₂₉ClN₆O₅

CAS No.

692054-06-1

SMILES

CC(N1CCN(CCOC2=CC3=NC=NC(NC4=C(OCO5)C5=NC=C4Cl)=C3C(OC(C)C)=C2)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AZD0424
Cat. No.:
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