1. Cell Cycle/DNA Damage
    Epigenetics
    PI3K/Akt/mTOR
  2. HDAC
    mTOR

HDACs/mTOR Inhibitor 1 

Cat. No.: HY-114414
Handling Instructions

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo.

For research use only. We do not sell to patients.

HDACs/mTOR Inhibitor 1 Chemical Structure

HDACs/mTOR Inhibitor 1 Chemical Structure

CAS No. : 2271413-06-8

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  • Biological Activity

  • Technical Information

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Description

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].

IC50 & Target[1]

HDAC1

0.19 nM (IC50)

HDAC6

1.8 nM (IC50)

mTOR

1.2 nM (IC50)

References
Molecular Weight

566.65

Formula

C₂₈H₃₈N₈O₅

CAS No.

2271413-06-8

SMILES

O=C(NO)CCCCCCN1C2=NC(C3=CC=C(NC(N4C[[email protected]@H](C)OCC4)=O)C=C3)=NC(N5CCOCC5)=C2C=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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HDACs/mTOR Inhibitor 1
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HY-114414
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HDACs/mTOR Inhibitor 1

Cat. No.: HY-114414