1. Cell Cycle/DNA Damage
    Epigenetics
    PI3K/Akt/mTOR
    Apoptosis
  2. HDAC
    mTOR
    Apoptosis
  3. HDACs/mTOR Inhibitor 1

HDACs/mTOR Inhibitor 1 

Cat. No.: HY-114414 Purity: 99.12%
Handling Instructions

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo.

For research use only. We do not sell to patients.

HDACs/mTOR Inhibitor 1 Chemical Structure

HDACs/mTOR Inhibitor 1 Chemical Structure

CAS No. : 2271413-06-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 561 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].

IC50 & Target[1]

HDAC1

0.19 nM (IC50)

HDAC6

1.8 nM (IC50)

mTOR

1.2 nM (IC50)

Molecular Weight

566.65

Formula

C₂₈H₃₈N₈O₅

CAS No.

2271413-06-8

SMILES

O=C(NO)CCCCCCN1C2=NC(C3=CC=C(NC(N4C[[email protected]@H](C)OCC4)=O)C=C3)=NC(N5CCOCC5)=C2C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 32.5 mg/mL (57.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7648 mL 8.8238 mL 17.6476 mL
5 mM 0.3530 mL 1.7648 mL 3.5295 mL
10 mM 0.1765 mL 0.8824 mL 1.7648 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

HDACs/mTOR Inhibitor 1HDACmTORApoptosisHistone deacetylasesMammalian target of RapamycinInhibitorinhibitorinhibit

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HDACs/mTOR Inhibitor 1
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HY-114414
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