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Cat. No.: HY-183587

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Anticancer agent 322

Anticancer agent 322 is a spirocyclohexane-chroman-4-one derivative. Anticancer agent 322 induces apoptosis and G1 cell cycle arrest in breast cancer cells. Anticancer agent 322 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₆ClNO₆
Molecular Weight:459.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 322 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

In Vitro

Anticancer agent 322 (Compound 42) potently inhibits MCF7 breast cancer cell viability with an IC₅₀ of 3.9 μM, while being 9.99-fold and 8.95-fold less cytotoxic to noncancerous MCF10A and VA13 cells, respectively, and moderately cytotoxic to MDAMB231 breast cancer cells^[1].
Anticancer agent 322 (20 μM; 24 h) induces G1-phase cell cycle arrest and slight apoptosis in MCF7 breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MCF7 breast cancer cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Induced a G1-phase cell cycle arrest in MCF7 cells, as shown by an increased percentage of cells in G1 phase relative to untreated controls.
Observed a slight but notable level of apoptosis in cell death analysis.

Chemical Information

Molecular Weight 459.92
Formula C₂₄H₂₆ClNO₆
SMILES

ClC(C=C1)=CC=C1NC(COC2=CC=C3C(OC4(CCC5(OCCO5)CC4)CC3O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ipatova DA, et al. Spirocyclohexane-Chroman-4-one Derivatives as Selectively Cytotoxic Agents in Breast Cancer Models. ACS Med Chem Lett. 2026;17(5):1114-1120. Published 2026 Apr 29. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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