2. Apoptosis Others
  3. Apoptosis Drug Derivative
  4. Anticancer agent 322

Anticancer agent 322 is a spirocyclohexane-chroman-4-one derivative. Anticancer agent 322 induces apoptosis and G1 cell cycle arrest in breast cancer cells. Anticancer agent 322 can be used for the research of breast cancer.

For research use only. We do not sell to patients.

Anticancer agent 322

Anticancer agent 322 Chemical Structure

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Anticancer agent 322 Related Antibodies

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Description

Anticancer agent 322 is a spirocyclohexane-chroman-4-one derivative. Anticancer agent 322 induces apoptosis and G1 cell cycle arrest in breast cancer cells. Anticancer agent 322 can be used for the research of breast cancer[1].

In Vitro

Anticancer agent 322 (Compound 42) potently inhibits MCF7 breast cancer cell viability with an IC50 of 3.9 μM, while being 9.99-fold and 8.95-fold less cytotoxic to noncancerous MCF10A and VA13 cells, respectively, and moderately cytotoxic to MDAMB231 breast cancer cells[1].
Anticancer agent 322 (20 μM; 24 h) induces G1-phase cell cycle arrest and slight apoptosis in MCF7 breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 322 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MCF7 breast cancer cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Induced a G1-phase cell cycle arrest in MCF7 cells, as shown by an increased percentage of cells in G1 phase relative to untreated controls.
Observed a slight but notable level of apoptosis in cell death analysis.
Molecular Weight

459.92

Formula

C24H26ClNO6
SMILES

ClC(C=C1)=CC=C1NC(COC2=CC=C3C(OC4(CCC5(OCCO5)CC4)CC3O)=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Anticancer agent 322 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 322Anticancer agent322Anticancer agent-322ApoptosisDrug DerivativeDrug derivativebreast cancerMCF7 cellsVA13 cellsMDAMB231 breast cancer cellsbreast cancer cellsapoptosisMCF10A cellsBT474 breast cancer cellsG1 cell cycle arrestInhibitorinhibitorinhibit

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