1. Apoptosis
  2. Apoptosis
  3. Anticancer agent 54

Anticancer agent 54 

Cat. No.: HY-146063
Handling Instructions

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation.

For research use only. We do not sell to patients.

Anticancer agent 54 Chemical Structure

Anticancer agent 54 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation[1].

In Vitro

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC50s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.
Molecular Weight

516.68

Formula

C33H36N6

SMILES

CCCCCCCCCCN1C=C(N=N1)C2=CC=C(C=C2)C3=CC(C4=NC=CC=C4)=NC(C5=CC=CC=N5)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anticancer agent 54
Cat. No.:
HY-146063
Quantity:
MCE Japan Authorized Agent: