country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-146063

Copy Link Print Information

Anticancer agent 54

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2933882-99-4
화학식: C₃₃H₃₆N₆
분자량:516.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 54 Chemical Structure

CAS No.: 2933882-99-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.75 μM Compound: Table 1, R1C1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
HCT-116	IC₅₀	0.27 μM Compound: Table 1, R1C1	Antiproliferative activity against human HCT 116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human HCT 116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	0.039 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CuSO4 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CuSO4 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	0.04 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CdSO4 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CdSO4 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeCl3 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeCl3 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeSO4 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeSO4 by MTS assay	[PMID: 31962262]
MCF7	IC₅₀	1 μM Compound: Table 1, R1C1	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of ZnCl2 by MTS assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of ZnCl2 by MTS assay	[PMID: 31962262]
NHDF	IC₅₀	20.83 μM Compound: Table 1, R1C1	Cytotoxicity against human NHDF cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Cytotoxicity against human NHDF cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
PANC-1	IC₅₀	0.44 μM Compound: Table 1, R1C1	Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]
U-251	IC₅₀	0.14 μM Compound: Table 1, R1C1	Antiproliferative activity against human U251 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay Antiproliferative activity against human U251 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay	[PMID: 31962262]

In Vitro

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC₅₀s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively^[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner^[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 2.5, 5 µM
Incubation Time:

24 h
Result:

Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

1, 2.5, 5 µM
Incubation Time:

24 h
Result:

The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.

Related Protocols :

Chemical Information

CAS No. 2933882-99-4
분자량 516.68
화학식 C₃₃H₃₆N₆
SMILES

CCCCCCCCCCN1C=C(N=N1)C2=CC=C(C=C2)C3=CC(C4=NC=CC=C4)=NC(C5=CC=CC=N5)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Malarz K,et al.Anticancer activity of 4'-phenyl-2,2':6',2″-terpyridines - behind the metal complexation. Eur J Med Chem. 2020 Mar 1;189:112039. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기