1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. CL-387785

CL-387785 (Synonyms: EKI-785; WAY-EKI 785)

Cat. No.: HY-10325 Purity: 97.06%
Handling Instructions

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370 pM.

For research use only. We do not sell to patients.

CL-387785 Chemical Structure

CL-387785 Chemical Structure

CAS No. : 194423-06-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 70 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 288 In-stock
Estimated Time of Arrival: December 31
50 mg USD 504 In-stock
Estimated Time of Arrival: December 31
100 mg USD 768 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370 pM.

IC50 & Target[1]

EGFR

370 pM (IC50)

Molecular Weight

381.23

Formula

C₁₈H₁₃BrN₄O

CAS No.

194423-06-8

SMILES

O=C(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)C#CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 13.67 mg/mL (35.86 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6231 mL 13.1154 mL 26.2309 mL
5 mM 0.5246 mL 2.6231 mL 5.2462 mL
10 mM 0.2623 mL 1.3115 mL 2.6231 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CL-387785EKI-785WAY-EKI 785CL387785CL 387785EKI785EKI 785EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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Product name:
CL-387785
Cat. No.:
HY-10325
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