2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. CL-387785

CL-387785  (Synonyms: EKI-785; WAY-EKI 785)

Cat. No.: HY-10325 Purity: 98.05%
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CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370 pM.

For research use only. We do not sell to patients.

CL-387785 Chemical Structure

CL-387785 Chemical Structure

CAS No. : 194423-06-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 77 In-stock
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Solid
2 mg USD 60 In-stock
5 mg USD 70 In-stock
10 mg USD 110 In-stock
25 mg USD 220 In-stock
50 mg USD 350 In-stock
100 mg USD 560 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

CL-387785 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CL-387785

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370 pM.

IC50 & Target

EGFR

370 pM (IC50)

Molecular Weight

381.23

Formula

C18H13BrN4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)C#CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 13.67 mg/mL (35.86 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6231 mL 13.1154 mL 26.2309 mL
5 mM 0.5246 mL 2.6231 mL 5.2462 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6231 mL 13.1154 mL 26.2309 mL 65.5772 mL
5 mM 0.5246 mL 2.6231 mL 5.2462 mL 13.1154 mL
10 mM 0.2623 mL 1.3115 mL 2.6231 mL 6.5577 mL
15 mM 0.1749 mL 0.8744 mL 1.7487 mL 4.3718 mL
20 mM 0.1312 mL 0.6558 mL 1.3115 mL 3.2789 mL
25 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6231 mL
30 mM 0.0874 mL 0.4372 mL 0.8744 mL 2.1859 mL
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CL-387785 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL-387785194423-06-8EKI-785 WAY-EKI 785CL387785CL 387785EKI785EKI 785EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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