Dihydrocucurbitacin B
Based on 1 Customer Validation
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity.
For research use only. We do not sell to patients.
- Purity: 96.76%
- CAS No.: 13201-14-4
- Formula: C32H48O8
- Molecular Weight:560.72
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.09 μM
Compound: 1, DHB
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 22472043] |
| A549 | IC50 |
19.91 μM
Compound: 1, DHB
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 22472043] |
| C8166 | CC50 |
25.5 μg/mL
Compound: 5
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Cytotoxicity against human C8166 cells by MTT method
Cytotoxicity against human C8166 cells by MTT method
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[PMID: 18088099] |
| C8166 | EC50 |
4.2 μg/mL
Compound: 5
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Antiviral activity against HIV1 in C8166 cells after 72 hrs
Antiviral activity against HIV1 in C8166 cells after 72 hrs
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[PMID: 18088099] |
| MCF7 | IC50 |
46.3 μM
Compound: 10
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
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[PMID: 25756299] |
Chemical Information
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CAS No. 13201-14-4
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Appearance Solid
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Molecular Weight 560.72
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Formula C32H48O8
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Color White to off-white
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SMILES
C[C@]12[C@@]([C@]([C@@](C)(O)C(CCC(C)(C)OC(C)=O)=O)([H])[C@H](O)C1)(CC([C@]3(C)[C@@]2([H])CC=C(C4(C)C)[C@@]3([H])C[C@H](O)C4=O)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (178.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7834 mL | 8.9171 mL | 17.8342 mL | 44.5855 mL |
| 5 mM | 0.3567 mL | 1.7834 mL | 3.5668 mL | 8.9171 mL | |
| 10 mM | 0.1783 mL | 0.8917 mL | 1.7834 mL | 4.4586 mL | |
| 15 mM | 0.1189 mL | 0.5945 mL | 1.1889 mL | 2.9724 mL | |
| 20 mM | 0.0892 mL | 0.4459 mL | 0.8917 mL | 2.2293 mL | |
| 25 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7834 mL | |
| 30 mM | 0.0594 mL | 0.2972 mL | 0.5945 mL | 1.4862 mL | |
| 40 mM | 0.0446 mL | 0.2229 mL | 0.4459 mL | 1.1146 mL | |
| 50 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8917 mL | |
| 60 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.7431 mL | |
| 80 mM | 0.0223 mL | 0.1115 mL | 0.2229 mL | 0.5573 mL | |
| 100 mM | 0.0178 mL | 0.0892 mL | 0.1783 mL | 0.4459 mL |
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