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製品番号: HY-162041

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AQIM-I

AQIM-I is an inhibitor of survivin via inhibits survivin expression and colony formation. AQIM-I induces ROS production, apoptosis, cell cycle arrest, DNA damage, and autophagy. AQIM-I inhibits nonsmall cell lung cancer cells A549 with an IC₅₀ value of 9 nM.

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CAS 番号: 2247881-73-6
分子式: C₁₇H₁₃IN₂O₂
分子量:404.20

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AQIM-I 構造式

CAS 番号: 2247881-73-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
143B	IC₅₀	0.59 μM Compound: 60; AQIM-I	Antiproliferative activity against human 143B cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human 143B cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
5637	IC₅₀	0.18 μM Compound: 60; AQIM-I	Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
A549	IC₅₀	0.009 μM Compound: 60; AQIM-I	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs in presence of scramble siRNA by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs in presence of scramble siRNA by MTT assay	[PMID: 38079530]
A549	IC₅₀	0.98 μM Compound: 60; AQIM-I	Antiproliferative activity against survivin silenced human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against survivin silenced human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
ASPC1	IC₅₀	0.25 μM Compound: 60; AQIM-I	Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
BXPC-3	IC₅₀	0.07 μM Compound: 60; AQIM-I	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
HeLa	IC₅₀	1.16 μM Compound: 60; AQIM-I	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
HepG2	IC₅₀	0.25 μM Compound: 60; AQIM-I	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
HUVEC	IC₅₀	6.66 μM Compound: 60; AQIM-I	Antiproliferative activity against human HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
MCF7	IC₅₀	0.06 μM Compound: 60; AQIM-I	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
MRC5	IC₅₀	6.9 μM Compound: 60; AQIM-I	Antiproliferative activity against human MRC5 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MRC5 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
NCI-H1299	IC₅₀	0.51 μM Compound: 60; AQIM-I	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
NCI-H460	IC₅₀	0.14 μM Compound: 60; AQIM-I	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
NIH3T3	IC₅₀	14 μM Compound: 60; AQIM-I	Antiproliferative activity against mouse NIH3T3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against mouse NIH3T3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
PANC-1	IC₅₀	0.08 μM Compound: 60; AQIM-I	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
TE-1	IC₅₀	0.05 μM Compound: 60; AQIM-I	Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]

化学情報

CAS 番号 2247881-73-6
分子量 404.20
分子式 C₁₇H₁₃IN₂O₂
SMILES

O=C1C2=C(C(C3=CC4=C(C=C31)C=CC=C4)=O)N(C=[N+]2C)C.[I-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jing Yuan, et al. Pioneering 4,11-Dioxo-4,11-dihydro-1 H-anthra[2,3- d]imidazol-3-ium Compounds as Promising Survivin Inhibitors by Targeting ILF3/NF110 for Cancer Therapy. J Med Chem. 2023. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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