CHMFL-48
CHMFL-48 is an orally active BCR-ABL kinase inhibitor targeting both wild-type (wt) and various imatinib-resistant mutants. The IC50 values for CHMFL-48 against ABL wild-type and ABL T315I mutant are 1 nM and 0.8 nM, respectively. CHMFL-48 exerts its effects by blocking the autophosphorylation of BCR-ABL wild-type and mutant forms, which impacts downstream signaling mediators such as STAT5 and CRKL, leading to cell cycle arrest and induction of apoptosis. CHMFL-48 holds potential for research into chronic myeloid leukemia (CML).
For research use only. We do not sell to patients.
- CAS No.: 2479290-65-6
- Formula: C31H30F3N7O
- Molecular Weight:573.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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WT BCR-ABL 1 nM (IC50) |
Bcr-AblT315I 0.8 nM (IC50) |
STAT5 |
Chemical Information
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CAS No. 2479290-65-6
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Molecular Weight 573.61
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Formula C31H30F3N7O
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SMILES
CC1=C(N2C=C(C3=CN=C(NC=C4)C4=C3)C=N2)C=C(NC(C5=CC=C(CN6CCN(C)CC6)C(C(F)(F)F)=C5)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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