MNK1/2-IN-8
MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest.
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- CAS 番号: 2430793-35-2
- 分子式: C26H24N6O
- 分子量:436.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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MNK1 0.8 nM (IC50) |
MNK2 1.5 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
1.73 μM
Compound: 15b
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Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
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[PMID: 38759457] |
| HL-60 | GI50 |
2.39 μM
Compound: 15b
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Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis
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[PMID: 38759457] |
| K562 | GI50 |
3.6 μM
Compound: 15b
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Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis
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[PMID: 38759457] |
| L02 | GI50 |
11.58 μM
Compound: 15b
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Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay
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[PMID: 38759457] |
| MOLM-13 | GI50 |
1.59 μM
Compound: 15b
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Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis
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[PMID: 38759457] |
体外実験
MNK1/2-IN-8 (compound 15b) inhibits cell growth with the GI50 of 7.68, 1.59, 3.60 and 2.39 μM against HCT-116,MOLM-13, K562 and HL-60, respectively[1].
MNK1/2-IN-8 (compound 15b) (1,2,and 4μM, 24 h) induces cell cycle arrest in MOLM-13 and K562 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2430793-35-2
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分子量 436.51
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分子式 C26H24N6O
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SMILES
O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MNK1/2-IN-8 関連分類
HY-158438 関連分類
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