2. MAPK/ERK Pathway
  3. MNK
  4. MNK1/2-IN-8

MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest.

For research use only. We do not sell to patients.

MNK1/2-IN-8

MNK1/2-IN-8 Chemical Structure

CAS No. : 2430793-35-2

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MNK1/2-IN-8 Related Antibodies

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Description

MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].

IC50 & Target

MNK1

0.8 nM (IC50)

MNK2

1.5 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HCT-116 GI50
1.73 μM
Compound: 15b
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay
[PMID: 38759457]
HL-60 GI50
2.39 μM
Compound: 15b
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis
[PMID: 38759457]
K562 GI50
3.6 μM
Compound: 15b
Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis
[PMID: 38759457]
L02 GI50
11.58 μM
Compound: 15b
Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay
Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay
[PMID: 38759457]
MOLM-13 GI50
1.59 μM
Compound: 15b
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis
Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis
[PMID: 38759457]
In Vitro

MNK1/2-IN-8 (compound 15b) inhibits cell growth with the GI50 of 7.68, 1.59, 3.60 and 2.39 μM against HCT-116,MOLM-13, K562 and HL-60, respectively[1].
MNK1/2-IN-8 (compound 15b) (1,2,and 4μM, 24 h) induces cell cycle arrest in MOLM-13 and K562 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MNK1/2-IN-8 Related Antibodies
In Vivo

MNK1/2-IN-8 (compound 15b) inhibits tumor growth in xenograft model of lung cancer LL/2 cells in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

436.51

Formula

C26H24N6O
CAS No.
SMILES

O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MNK1/2-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK1/2-IN-82430793-35-2MNKMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseMOLM-13K562cell cycleLL/2 syngeneic modelHCT-116HL-60Inhibitorinhibitorinhibit

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