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Cat. No.: HY-158438

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MNK1/2-IN-8

MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC₅₀ values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest.

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CAS No.: 2430793-35-2
Formule: C₂₆H₂₄N₆O
Masse moléculaire:436.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MNK1/2-IN-8 Chemical Structure

CAS No.: 2430793-35-2

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

MNK1

0.8 nM (IC₅₀)

MNK2

1.5 nM (IC₅₀)

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Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	1.73 μM Compound: 15b	Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay	[PMID: 38759457]
HL-60	GI₅₀	2.39 μM Compound: 15b	Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis Antiproliferative activity against human HL-60 cells incubated for 72 hrs by trypan blue staining based analysis	[PMID: 38759457]
K562	GI₅₀	3.6 μM Compound: 15b	Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis Antiproliferative activity against human K562 cells incubated for 72 hrs by trypan blue staining based analysis	[PMID: 38759457]
L02	GI₅₀	11.58 μM Compound: 15b	Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human L02 cells incubated for 96 hrs by MTT assay	[PMID: 38759457]
MOLM-13	GI₅₀	1.59 μM Compound: 15b	Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by trypan blue staining based analysis	[PMID: 38759457]

In Vitro

MNK1/2-IN-8 (compound 15b) inhibits cell growth with the GI₅₀ of 7.68, 1.59, 3.60 and 2.39 μM against HCT-116,MOLM-13, K562 and HL-60, respectively^[1].
MNK1/2-IN-8 (compound 15b) (1,2,and 4μM, 24 h) induces cell cycle arrest in MOLM-13 and K562 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MNK1/2-IN-8 (compound 15b) inhibits tumor growth in xenograft model of lung cancer LL/2 cells in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2430793-35-2
Masse moléculaire 436.51
Formule C₂₆H₂₄N₆O
SMILES

O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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MNK1/2-IN-8

Voir tous les produits spécifiques à Isoform MNK