1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Tubulysin I

Tubulysin I 

Cat. No.: HY-N7052
Handling Instructions

Tubulysin I is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

For research use only. We do not sell to patients.

Tubulysin I Chemical Structure

Tubulysin I Chemical Structure

CAS No. : 799822-10-9

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Description

Tubulysin I is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Molecular Weight

801.99

Formula

C₄₀H₅₉N₅O₁₀S

CAS No.

799822-10-9

SMILES

O=C([[email protected]@H]1N(CCCC1)C)N[[email protected]]([[email protected]@H](C)CC)([H])C(N(COC(C)=O)[[email protected]@H](C(C)C)C[[email protected]](C2=NC(C(N[[email protected]](C[[email protected]](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O)=O

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