EGFR-IN-191
EGFR-IN-191 is an anti-tumor agent targeting both EGFR and AKT. EGFR-IN-191 exerts its anti-tumor activity by inducing DNA damage, apoptosis, cell cycle arrest, and inhibition of the PI3K/AKT-EGFR signaling pathway in tumor cells. EGFR-IN-191 can be used in the study of tumors such as triple-negative breast cancer.
For research use only. We do not sell to patients.
- Formula: C32H35NO8
- Molecular Weight:561.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EGFR-IN-191 (Compound 2J) (0-20 μM; 48 h) inhibits the proliferation of MDA-MB-231, MCF-7, and Hs 578Bst cells, with IC50 values of 6.89 μM, 7.79 μM, and 10.19 μM, respectively[1].
EGFR-IN-191 (0-20 μM; 0-48 h) induces apoptosis, cell cycle arrest, DNA damage, and reduces mitochondrial membrane potential in MDA-MB-231 cells[1].
EGFR-IN-191 (7-14.0 μM) downregulates the protein expression of EGFR, p-EGFR, and p-AKT in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:7.0, 10.5 and 14.0 μM
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Incubation Time:24 h
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Result:Upregulated mRNA expression of Bax, BRCA1, CDKN1A, Caspase-3, PIK3CA, Mcl-1.
Slightly downregulated Bcl-2 and p53.
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Cell Line:MDA-MB-231
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Concentration:7.0, 10.5 and 14.0 μM
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Incubation Time:24 h
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Result:Increased sub-G₀/G₁ cell accumulation dose-dependently (15.01% at 7.0 μM, 23.16% at 10.5 μM, 32.19% at 14.0 μM vs. 11.11% in control)
Induced G₂/M phase arrest (22.36% at 10.5 μM).
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Cell Line:MDA-MB-231
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Concentration:7.0, 10.5 and 14.0 μM
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Incubation Time:24 h
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Result:Increased total apoptotic cells (early + late) to 8.44% at 7.0 μM, 22.84% at 10.5 μM, and 40.83% at 14.0 μM.
Increased necrotic cells to 9.36% at 14.0 μM.
Chemical Information
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Molecular Weight 561.62
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Formula C32H35NO8
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SMILES
CC1=C(OC([C@H](CC2=CC=C(O)C=C2)NC(OC(C)(C)C)=O)=O)C(C)=C(O)C(C(/C=C/C3=CC=CC=C3)=O)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-191 Related Classifications
HY-181093 Related Classifications
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