2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. ADC Payload Apoptosis
  4. ProAlk01

ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors.

For research use only. We do not sell to patients.

ProAlk01

ProAlk01 Chemical Structure

CAS No. : 1296670-84-2

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ProAlk01 Related Antibodies

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Description

ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors[1].

In Vitro

ProAlk01 (1-100 pM) exhibits potent in vitro cytotoxic activity across a broad panel of solid tumor cell lines with IC50 values in the 1-100 pM range[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ProAlk01 Related Antibodies
Molecular Weight

563.47

Formula

C31H28Cl2N2O4
CAS No.
SMILES

O=C(N1C[C@H](C2=C1C=C(C3=C2C=CC=C3)O)CCl)CCCC(N4C[C@H](C5=C4C=C(C6=C5C=CC=C6)O)CCl)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ProAlk01 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ProAlk011296670-84-2ProAlk 01ProAlk-01ADC PayloadApoptosisADC Cytotoxinsolid tumor cell linesimmunogenic cell deathDXd-resistant cancer cellsapoptosiscell cycle arrestcytosolABCG2solid tumorsS-phaseABCB1Inhibitorinhibitorinhibit

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