EGFR-IN-152
EGFR-IN-152 (compound D4) is a potent EGFR tyrosine kinase inhibitor, exhibiting potent EGFRL858R/T790M/C797S inhibition activity (IC50 = 40 nM). EGFR-IN-152 induces G0/G1 phase cell cycle arrest and apoptosis, thereby inhibiting colony formation and cell proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 can be used for NSCLC research.
For research use only. We do not sell to patients.
- CAS No.: 2463197-87-5
- Formula: C29H35N9O2S
- Molecular Weight:573.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
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EGFR (C797S/T790M/L858R) 40 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
1.67 μM
Compound: D4
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Antiproliferative activity against human A-431 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells incubated for 72 hrs by MTT assay
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[PMID: 31787359] |
Chemical Information
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CAS No. 2463197-87-5
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Molecular Weight 573.71
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Formula C29H35N9O2S
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SMILES
CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N([C@@H]5CN(CC5)S(=O)(C6CC6)=O)C(NC7=CC=CC=C7)=N4)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)