EGFR-IN-152
EGFR-IN-152 (compound D4) is a potent EGFR tyrosine kinase inhibitor, exhibiting potent EGFRL858R/T790M/C797S inhibition activity (IC50 = 40 nM). EGFR-IN-152 induces G0/G1 phase cell cycle arrest and apoptosis, thereby inhibiting colony formation and cell proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 can be used for NSCLC research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2463197-87-5
- 分子式: C29H35N9O2S
- 分子量:573.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
EGFR アイソフォーム固有の製品をすべて表示
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生物活性
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EGFR (C797S/T790M/L858R) 40 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
1.67 μM
Compound: D4
|
Antiproliferative activity against human A-431 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells incubated for 72 hrs by MTT assay
|
[PMID: 31787359] |
化学情報
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CAS 番号 2463197-87-5
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分子量 573.71
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分子式 C29H35N9O2S
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SMILES
CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N([C@@H]5CN(CC5)S(=O)(C6CC6)=O)C(NC7=CC=CC=C7)=N4)=N3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)