2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-152

EGFR-IN-152 (compound D4) is a potent EGFR tyrosine kinase inhibitor, exhibiting potent EGFRL858R/T790M/C797S inhibition activity (IC50 = 40 nM). EGFR-IN-152 induces G0/G1 phase cell cycle arrest and apoptosis, thereby inhibiting colony formation and cell proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 can be used for NSCLC research.

For research use only. We do not sell to patients.

EGFR-IN-152

EGFR-IN-152 Chemical Structure

CAS No. : 2463197-87-5

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EGFR-IN-152 Related Antibodies

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Description

EGFR-IN-152 (compound D4) is a potent EGFR tyrosine kinase inhibitor, exhibiting potent EGFRL858R/T790M/C797S inhibition activity (IC50 = 40 nM). EGFR-IN-152 induces G0/G1 phase cell cycle arrest and apoptosis, thereby inhibiting colony formation and cell proliferation of non-small cell lung cancer (NSCLC) cells. EGFR-IN-152 can be used for NSCLC research[1].

IC50 & Target[1]

EGFR (C797S/T790M/L858R)

40 nM (IC50)

Molecular Weight

573.71

Formula

C29H35N9O2S
CAS No.
SMILES

CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C4C(N([C@@H]5CN(CC5)S(=O)(C6CC6)=O)C(NC7=CC=CC=C7)=N4)=N3
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Purity & Documentation
References
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EGFR-IN-152 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-1522463197-87-5EGFRApoptosisEpidermal growth factor receptorErbB-1HER1G0/G1 phase cell cycle arrestEGFRL858R/T790M/C797SNSCLCHCC827Inhibitorinhibitorinhibit

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