1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Apoptosis
  3. CDK2-IN-9

CDK2-IN-9 

Cat. No.: HY-144811
Handling Instructions

CDK2-IN-9 is a potent CDK2 inhibitor with an IC50 of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma.

For research use only. We do not sell to patients.

CDK2-IN-9 Chemical Structure

CDK2-IN-9 Chemical Structure

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Description

CDK2-IN-9 is a potent CDK2 inhibitor with an IC50 of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma[1].

IC50 & Target[1]

CDK2

0.63 μM (IC50)

In Vitro

CDK2-IN-9 (compound 5c) shows antiproliferative activity with IC50s of 3.03, 8.62, 62.52 µM for MDA-MB-435, SNB-75, WI-38 cells, respectively[1].
CDK2-IN-9 (24 h) induces apoptosis and cell cycle arrest in S and G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MDA-MB-435, SNB-75 cells
Concentration: 3.03for MDA-MB-435 cells, 8.62 for SNB-75 cells
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-435 and SNB-75 cells with the percent of the total apoptosis of 28.65 and 44.22%, respectively.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435, SNB-75 cells
Concentration:
Incubation Time: 24 h
Result: Induced cell cycle arrest at S phase and G2/M.
Molecular Weight

441.89

Formula

C21H16ClN3O4S

SMILES

O=S(C1=CC=C(Cl)C=C1)(NN2C(COC3=CC=CC=C3)=NC4=C(C=CC=C4)C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
CDK2-IN-9
Cat. No.:
HY-144811
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