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Cat. No.: HY-143447

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Tubulin polymerization-IN-8

Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC₅₀ value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases^{[ 1]}.

For research use only. We do not sell to patients.

CAS No.: 2768485-08-9
Formula: C₂₁H₂₄N₄O₄S
Molecular Weight:428.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Tubulin polymerization-IN-8 Chemical Structure

CAS No.: 2768485-08-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	1.46 μM Compound: IIc	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HEK293	IC₅₀	>100 μM Compound: IIc	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HeLa	IC₅₀	9.02 μM Compound: IIc	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HepG2	IC₅₀	3.65 μM Compound: IIc	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]
HT-29	IC₅₀	0.62 μM Compound: IIc	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth by MTT assay	[PMID: 35398303]

Chemical Information

CAS No. 2768485-08-9
Molecular Weight 428.50
Formula C₂₁H₂₄N₄O₄S
SMILES

COC1=CC(CC2=NN=C(N2N)SCC(C3=CC=C(C=C3)C)=O)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen L, et al. Concise synthesis and preliminary biological evaluation of new triazolylthioacetone derivatives bearing pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment. Bioorg Med Chem Lett. 2022;66:128721. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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