Anticancer agent 57
Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC).
For research use only. We do not sell to patients.
- CAS No.: 2408017-71-8
- Formula: C20H21Cl2NO2
- Molecular Weight:378.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 8.00 ± 0.07 μM in MDA-MB-231, 7.30 ± 0.04 μM in MDA-MB-468, 6.43 ± 0.18 μM in MCF-7[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
2.44 μM
Compound: 14
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Antimigratory activity in human MCF7 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
Antimigratory activity in human MCF7 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
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[PMID: 31838326] |
| MCF7 | IC50 |
6.43 μM
Compound: 14
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
| MDA-MB-231 | IC50 |
3 μM
Compound: 14
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Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
|
[PMID: 31838326] |
| MDA-MB-231 | IC50 |
3.94 mM
Compound: Fig 1C, Cpd 2
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Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
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[PMID: 38750906] |
| MDA-MB-231 | IC50 |
8 μM
Compound: 14
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
|
[PMID: 31838326] |
| MDA-MB-468 | IC50 |
7.3 μM
Compound: 14
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
Chemical Information
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CAS No. 2408017-71-8
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Molecular Weight 378.29
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Formula C20H21Cl2NO2
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SMILES
O=C(C1=CC=CC(OC)=C1)/C=C/C2=CC=C(N(CCCl)CCCl)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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