1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulysin D

Tubulysin D 

Cat. No.: HY-N2348
Handling Instructions

Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range.

For research use only. We do not sell to patients.

Tubulysin D Chemical Structure

Tubulysin D Chemical Structure

CAS No. : 309935-57-7

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Description

Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2].

IC50 & Target

IC50: 1.7 μM (Tubulin)[1]

In Vitro

Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1].

Molecular Weight

828.07

Formula

C₄₃H₆₅N₅O₉S

CAS No.

309935-57-7

SMILES

CC(O[[email protected]@H](C1=NC(C(N[[email protected]](C[[email protected]](C)C(O)=O)CC2=CC=CC=C2)=O)=CS1)C[[email protected]](C(C)C)N(COC(CC(C)C)=O)C([[email protected]@]([[email protected]@H](C)CC)([H])NC([[email protected]@H](CCCC3)N3C)=O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Tubulysin D
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