2. Apoptosis
  3. c-Myc
  4. APTO-253 hydrochloride

APTO-253 hydrochloride  (Synonyms: LOR-253 hydrochloride; LT-253 hydrochloride)

Cat. No.: HY-16291A
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APTO-253?(LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253?hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4?(KLF4)?tumor suppressor. APTO-253?hydrochloride exhibits antiarthritic activity.

For research use only. We do not sell to patients.

CAS No. : 1691221-67-6

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APTO-253 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Blood. 2024 Aug 16:blood.2023023644.  [Abstract]

    Cell viability of OCI-AML2 cells expressing either sgLuc or sgPCGF1 was assessed under the treatment of APTO-253 (100 nM; 9 d).

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 2;14(1):5360.  [Abstract]

    APTO-253 (10 μM) reversed the effects of FAM3A on suppressing the expression of the markers for macrophages (CD68) and osteoblasts (OPN, RUNX2) in VSMCs.

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 2;14(1):5360.  [Abstract]

    KLF4 inducer APTO-253 (1 μg/g; i.p.; once daily for 4 weeks) significantly abrogated the effects of FAM3A on maintaining the contractile phenotype of VSMCs in aortas from AngII-ApoE−/− murine AAA models.

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2021 Apr;80(4):440-450.  [Abstract]

    APTO-253 (1-4 μM) reduced mRNA levels of 8-mix SE-contacted genes (IL-6, CCL5) in stimulated RASFs.

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2021 Apr;80(4):440-450.  [Abstract]

    APTO-253 (15 mg/kg; i.v.; twice per day for two consecutive days per week) demonstrated significant therapeutic activity in collagen-induced arthritis (CIA) mice.

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    Description

    APTO-253?(LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253?hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4?(KLF4)?tumor suppressor. APTO-253?hydrochloride exhibits antiarthritic activity[1].

    Molecular Weight

    367.38

    Formula

    C22H14FN5
    CAS No.
    SMILES

    CC(NC1=C2C=C(F)C=C1)=C2C3=NC4=C5C=CC=NC5=C6N=CC=CC6=C4N3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    APTO-253 hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    APTO-2531691221-67-6LOR-253LT-253APTO253APTO 253LOR253LOR 253LT253LT 253c-MycMycInhibitorinhibitorinhibit

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