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APTO-253 hydrochloride

(Synonyms: LOR-253 hydrochloride; LT-253 hydrochloride)
23 Cited Publications
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Based on 23 publication(s) in Google Scholar

APTO-253?(LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253?hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4?(KLF4)?tumor suppressor. APTO-253?hydrochloride exhibits antiarthritic activity.

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  • CAS. Nr.: 1691221-67-6
  • Formel: C22H14FN5
  • Molecular Weight:367.38
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • APTO-253 hydrochloride Chemical Structure
    APTO-253 hydrochloride Chemical Structure
  • Experimental Validation Results for APTO-253 hydrochloride
  • Experimental Validation Results for APTO-253 hydrochloride
  • Experimental Validation Results for APTO-253 hydrochloride
  • Experimental Validation Results for APTO-253 hydrochloride
  • Experimental Validation Results for APTO-253 hydrochloride
CAS. Nr.: 1691221-67-6
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Cell Proliferation/Viability AssayRT-PCRWBIn Vivo Efficacy Study
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  • In Vivo Efficacy Study

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  • APTO-253 hydrochloride Chemical Structure
    APTO-253 hydrochloride Chemical Structure
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  • 1/16

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Blood. 2024 Nov 7;144(19):2018-2032. [Abstract]

    Customer Validation
     Cell viability of OCI-AML2 cells expressing either sgLuc or sgPCGF1 was assessed under the treatment of APTO-253 (100 nM; 9 d).

  • 1/16

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 2;14(1):5360. [Abstract]

    Customer Validation
     APTO-253 (10 μM) reversed the effects of FAM3A on suppressing the expression of the markers for macrophages (CD68) and osteoblasts (OPN, RUNX2) in VSMCs.

  • 1/16

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 2;14(1):5360. [Abstract]

    Customer Validation
     KLF4 inducer APTO-253 (1 μg/g; i.p.; once daily for 4 weeks) significantly abrogated the effects of FAM3A on maintaining the contractile phenotype of VSMCs in aortas from AngII-ApoE−/− murine AAA models.

  • 1/16

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2021 Apr;80(4):440-450. [Abstract]

    Customer Validation
     APTO-253 (1-4 μM) reduced mRNA levels of 8-mix SE-contacted genes (IL-6, CCL5) in stimulated RASFs.

  • 1/16

    APTO-253 hydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2021 Apr;80(4):440-450. [Abstract]

    Customer Validation
     APTO-253 (15 mg/kg; i.v.; twice per day for two consecutive days per week) demonstrated significant therapeutic activity in collagen-induced arthritis (CIA) mice.

  • APTO-253 hydrochloride