Tubulin inhibitor 24 

Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity^[1].

Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC₅₀s of 0.021, 0.047, 0.003, 0.048 µM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively^[1].
Tubulin inhibitor 24 inhibites tubulin polymerization with an IC₅₀ value of 2.1 µM^[1].
Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner^[1].
Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner^[1].
Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

375.42

C₂₂H₂₁N₃O₃

2415761-65-6

COC1=CC(C2=CC=NC3=CC(C4=CC=C(C=C4)C)=NN32)=CC(OC)=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li G,et al. Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities. Eur J Med Chem. 2020; 202:112519.  [Content Brief]