1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Tubulysin E

Tubulysin E 

Cat. No.: HY-N2346
Handling Instructions

Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

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Tubulysin E Chemical Structure

Tubulysin E Chemical Structure

CAS No. : 309935-58-8

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Description

Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Molecular Weight

814.04

Formula

C₄₂H₆₃N₅O₉S

CAS No.

309935-58-8

SMILES

CC(O[[email protected]@H](C1=NC(C(N[[email protected]](C[[email protected]](C)C(O)=O)CC2=CC=CC=C2)=O)=CS1)C[[email protected]](C(C)C)N(COC(CCC)=O)C([[email protected]@]([[email protected]@H](C)CC)([H])NC([[email protected]@H](CCCC3)N3C)=O)=O)=O

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