Tubulin polymerization-IN-43
Based on 1 Customer Validation
Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 2773345-90-5
- Formula: C17H13F4N3O
- Molecular Weight:351.30
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
0.099 μM
Compound: 15h
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Cytotoxicity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HEL cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37201429] |
| HeLa | IC50 |
0.11 μM
Compound: 15h
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Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 37201429] |
| K562 | IC50 |
0.265 μM
Compound: 15h
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Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37201429] |
| L02 | IC50 |
1.95 μM
Compound: 15h
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Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37201429] |
| LNCaP | IC50 |
0.377 μM
Compound: 15h
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Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 37201429] |
Tubulin polymerization-IN-43 (compound 15h; 0.001-10 μM; 48 h) results in a significant reduction in the number of HEL and K562 cells[1].
Tubulin polymerization-IN-43 (0.5 μM; 48 h) induces cell apoptosis and promotes cell cycle arrest of leukemia cells at G2/M phase[1].
Tubulin polymerization-IN-43 (0.5 μM; 24 h) significantly inhibits the migration rate of HUVEC cells[1].
Tubulin polymerization-IN-43 (0.2, 1, 5, and 25 μM) could induce the antimitotic effect of K562 cells by directly binding to the colchicine binding site of β-tubulin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Chronic myeloid leukemia cells (K562), erythroleukemia cells (HEL), human prostate cancer cells (LNCaP), and cervical cancer cells (HeLa)
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Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
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Incubation Time:48 h
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Result:Showed anti-tumor activity against HeLa, HEL, K562, and LNCaP cells with IC50s of 0.011 μM, 0.099 μM, 0.265 μM, and 0.377 μM, respectively.
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Cell Line:K562 and HEL cells
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Concentration:0.5 μM
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Incubation Time:48 h
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Result:Significantly induced apoptosis.
Chemical Information
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CAS No. 2773345-90-5
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Appearance Solid
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Molecular Weight 351.30
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Formula C17H13F4N3O
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Color White to off-white
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SMILES
FC1=CC2=C(N=C(C(F)(F)F)N=C2N(C)C3=CC=C(OC)C=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (284.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8466 mL | 14.2328 mL | 28.4657 mL | 71.1642 mL |
| 5 mM | 0.5693 mL | 2.8466 mL | 5.6931 mL | 14.2328 mL | |
| 10 mM | 0.2847 mL | 1.4233 mL | 2.8466 mL | 7.1164 mL | |
| 15 mM | 0.1898 mL | 0.9489 mL | 1.8977 mL | 4.7443 mL | |
| 20 mM | 0.1423 mL | 0.7116 mL | 1.4233 mL | 3.5582 mL | |
| 25 mM | 0.1139 mL | 0.5693 mL | 1.1386 mL | 2.8466 mL | |
| 30 mM | 0.0949 mL | 0.4744 mL | 0.9489 mL | 2.3721 mL | |
| 40 mM | 0.0712 mL | 0.3558 mL | 0.7116 mL | 1.7791 mL | |
| 50 mM | 0.0569 mL | 0.2847 mL | 0.5693 mL | 1.4233 mL | |
| 60 mM | 0.0474 mL | 0.2372 mL | 0.4744 mL | 1.1861 mL | |
| 80 mM | 0.0356 mL | 0.1779 mL | 0.3558 mL | 0.8896 mL | |
| 100 mM | 0.0285 mL | 0.1423 mL | 0.2847 mL | 0.7116 mL |
Tubulin polymerization-IN-43 Related Classifications
HY-149363 Related Classifications
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