EGFR-IN-171
EGFR-IN-171 is an EGFR inhibitor with an IC50 value of 0.19 μM. EGFR-IN-171 also inhibits vascular endothelial growth factor 2 (VEGFR-2) with an IC50 value of 31.65 μM. EGFR-IN-171 can induce apoptosis and G2/M phase cell cycle arrest. EGFR-IN-171 can be used for cancer research, such as liver and breast cancer.
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- Formule: C32H26N4O3S
- Masse moléculaire:546.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
EGFR-IN-171 (Compound 6b) shows cytotoxic in HepG-2, MCF-7 and HCT-116 cells with IC50 vales of 5.8, 3.91 and 7.97 μM, respectively[1].
EGFR-IN-171 (3.91 μM, 24 h) increases apoptosis and cell accumulation in the G2/M phase in MCF-7 cells[1].
EGFR-IN-171 (3.91 μM, 24 h) increases Bax and p53 levels and decreases Bcl-2 levels in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:3.91 μM
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Incubation Time:24 h
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Result:Led to a notable increase in late apoptosis from 0.18% to 15.39%.
Increased early apoptosis from 0.35% to 8.92%.
Displayed a 6.3-fold rise in Bax levels.
Increased the amount of p53 protein by 7.2 times.
Downregulated Bcl-2 levels by 2.6 times.
Chemical Information
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Masse moléculaire 546.64
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Formule C32H26N4O3S
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SMILES
O=C1N(C2=CC=CC=C2)C(SC3=COC(C)=C3C4CC(C5=CC=CO5)NC6=CC=CC=C6N4)=NC7=C1C=CC=C7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-171 Related Classifications
HY-175608 Related Classifications
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