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Cat. No.: HY-156279

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HDAC6-IN-22

HDAC6-IN-22 (compound 30) is a inhibitor of HDAC6, with the IC₅₀ of 4.63 nM. HDAC6-IN-22 has antiproliferative effects in vitro and in vivo towards multiple myeloma. HDAC6-IN-22 induces cell cycle arrest in the G2 phase and promotes apoptosis through the mitochondrial pathway.

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Formule: C₂₄H₂₄N₄O₂
Masse moléculaire:400.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HDAC6-IN-22 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

4.63 nM (HDAC6)^[1]

Voir tous les produits spécifiques à Isoform HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
HCCLM3	IC₅₀	>50 μM Compound: 29	Cytotoxicity against human HCCLM3 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human HCCLM3 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 37797564]
HCT-116	IC₅₀	5.521 μM Compound: 29	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 37797564]
MDA-MB-468	IC₅₀	43.99 μM Compound: 29	Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 37797564]
RPMI-8226	IC₅₀	2.037 μM Compound: 29	Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 37797564]
SGC-7901	IC₅₀	40.85 μM Compound: 29	Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 37797564]

Chemical Information

Masse moléculaire 400.47
Formule C₂₄H₂₄N₄O₂
SMILES

CN1C2=CC=C(C(NO)=O)C=C2N=C1[C@H](CC3=CC=CC=C3)NCC4=CC=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu L, et al. Design and synthesis of 1H-benzo[d]imidazole selective HDAC6 inhibitors with potential therapy for multiple myeloma [published online ahead of print, 2023 Sep 25]. Eur J Med Chem. 2023;261:115833. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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HDAC6-IN-22

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HDAC6-IN-22 Related Classifications

HY-156279 Related Classifications

Bioz

Keywords

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