HDAC6-IN-22
HDAC6-IN-22 (compound 30) is a inhibitor of HDAC6, with the IC50 of 4.63 nM. HDAC6-IN-22 has antiproliferative effects in vitro and in vivo towards multiple myeloma. HDAC6-IN-22 induces cell cycle arrest in the G2 phase and promotes apoptosis through the mitochondrial pathway.
For research use only. We do not sell to patients.
- Formula: C24H24N4O2
- Molecular Weight:400.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
4.63 nM (HDAC6)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCCLM3 | IC50 |
>50 μM
Compound: 29
|
Cytotoxicity against human HCCLM3 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HCCLM3 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 37797564] |
| HCT-116 | IC50 |
5.521 μM
Compound: 29
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 37797564] |
| MDA-MB-468 | IC50 |
43.99 μM
Compound: 29
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Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 37797564] |
| RPMI-8226 | IC50 |
2.037 μM
Compound: 29
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Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 37797564] |
| SGC-7901 | IC50 |
40.85 μM
Compound: 29
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Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 37797564] |
Chemical Information
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Molecular Weight 400.47
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Formula C24H24N4O2
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SMILES
CN1C2=CC=C(C(NO)=O)C=C2N=C1[C@H](CC3=CC=CC=C3)NCC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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