Albanol B
Based on 1 Customer Validation
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.66%
- No. CAS: 87084-99-9
- Fòrmula: C34H22O8
- Peso molecular:558.53
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Albanol B (10 μM, 30 μM; 24 h) decreases cell viability of A549 cells[1].
Albanol B (30 μM; 48 h) arrrests cell cycle at G2/M phase and induces apoptosis in A549 and H1975 cells[1].
Albanol B (1-30 μM; 1-9 h) mediates the activation of ERK-1/2 and AKT in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells, BZR, NCI-H1975, and NCI-H226 cells
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Concentration:0, 1, 3, 10, and 30 μM
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Incubation Time:48 hours
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Result:Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively.
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Cell Line:A549 and H1975 cells
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Concentration:1, 3, 10 μM
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Incubation Time:48 hours
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Result:Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively.
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Cell Line:A549 cells
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Concentration:1 h, 3 h, 6 h, and 9 h
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Incubation Time:48 hours
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Result:Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners.
Did not increase the phosphorylation level of JNK and p38 MAPKs.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:EX-3LL tumor-bearing mice[1]
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Dosage:50 mg/kg, 100 mg/kg
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Administration:IP; once daily for 21 days
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Result:Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
- RNA extraction experimental
- Western Blot
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- ROS/oxidative-stress fluorescent staining
- Protocol for Cell Cycle
- Alzheimer’s Disease Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- Kinase activity and phosphorylation assays
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Apoptosis Solutions
- Protocol for Kinase activity and phosphorylation assays
Chemical Information
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No. CAS 87084-99-9
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Appearance Solid
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Peso molecular 558.53
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Fòrmula C34H22O8
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Color Off-white to gray
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SMILES
OC1=C(C=CC(O)=C1)[C@@]23C4=C(C5=CC=C(O)C=C5O3)C=C(C)C=C4C6=C(O)C=C(C(OC7=C8)=CC7=CC=C8O)C=C6O2
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Albanol B Related Classifications
HY-N11439 Related Classifications
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