c-Met/HDAC-IN-3
c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase.
For research use only. We do not sell to patients.
- CAS No.: 2439175-23-0
- Formula: C34H35FN4O7
- Molecular Weight:630.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 26.97 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.28 μM
Compound: 49a
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Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
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[PMID: 37875056] |
| A549 | IC50 |
1.08 μM
Compound: 74
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Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
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[PMID: 34052677] |
| HCT-116 | IC50 |
0.28 μM
Compound: 49a
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Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay
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[PMID: 37875056] |
| HCT-116 | IC50 |
0.54 nM
Compound: 74
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 34052677] |
| MCF7 | IC50 |
0.28 μM
Compound: 49a
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Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
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[PMID: 37875056] |
c-Met/HDAC-IN-3 (Compound 15f) (0-20 μM, 72 h) shows antiproliferative activities against HCT-116, MCF-7 and A549 cells[1].
c-Met/HDAC-IN-3 (0-5 μM, 48 h) induces apoptosis and arrests cell cycle at G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, MCF-7 and A549
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Concentration:0-20 µM
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Incubation Time:72 h
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Result:Showed antiproliferative activities with IC50 values of 0.54 ± 0.05, 0.28 ± 0.02 and 1.08 ± 0.44 μM against HCT-116, MCF-7 and A549 cells.
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Cell Line:HCT-116
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Concentration:0.2, 1.0 and 5.0 µM
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Incubation Time:48 h
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Result:Resulted in 6.97%, 7.08% and 13.21% cells apoptosis at 0.2, 1.0 and 5.0 µM, respectively.
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Cell Line:HCT-116
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Concentration:0.2, 1.0 and 5.0 µM
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Incubation Time:48 h
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Result:Showed an obvious increase in the proportion of cells in G2/M phase in a dose-dependent manner.
Chemical Information
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CAS No. 2439175-23-0
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Molecular Weight 630.66
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Formula C34H35FN4O7
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SMILES
COC1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C=C3)NC(C4CCN(C4=O)C5=CC=C(C=C5)F)=O)OCCCCCCC(NO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met/HDAC-IN-3 Related Classifications
HY-150004 Related Classifications
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