2439175-23-0
Chemical Structure
c-Met/HDAC-IN-3
- CAS No.: 2439175-23-0
- Formula:C34H35FN4O7
- Molecular Weight:630.66
IUPAC Name: 1-(4-fluorophenyl)-N-(4-((7-((7-(hydroxyamino)-7-oxoheptyl)oxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-2-oxopyrrolidine-3-carboxamide
InChIKey: BLMPKINHBQAHPE-UHFFFAOYSA-N
SMILES: COC1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C=C3)NC(C4CCN(C4=O)C5=CC=C(C=C5)F)=O)OCCCCCCC(NO)=O
Biological Activity: c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase[1].
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c-Met/HDAC-IN-3 | c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase. | |||||||||||||||||||||
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Keywords
