VEGFR-2-IN-23
VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase.
For research use only. We do not sell to patients.
- CAS No.: 2411174-53-1
- Formula: C22H15N5O2
- Molecular Weight:381.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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VEGFR-2 0.19 nM (IC50) |
VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC50s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2411174-53-1
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Molecular Weight 381.39
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Formula C22H15N5O2
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SMILES
N#CC1=C(N=C(C=C1C2=CC=C(C=C2)[N+]([O-])=O)C3=CC4=CC=CC=C4C=C3)NN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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