MDM2-p53-IN-16
Based on 1 Customer Validation
MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research.
For research use only. We do not sell to patients.
- Purity: 99.08%
- CAS No.: 1917350-09-4
- Formula: C32H33N3O5
- Molecular Weight:539.62
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Anti-Cancer Compound Library
HY-L025
-
Autophagy Compound Library
HY-L029
-
Anti-Aging Compound Library
HY-L034
-
Covalent Screening Library
HY-L036
-
Reprogramming Compound Library
HY-L039
-
Ferroptosis Compound Library
HY-L051
-
Pyroptosis Compound Library
HY-L059
-
Glutamine Metabolism Compound Library
HY-L064
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Anti-Blood Cancer Compound Library
HY-L079
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Transcription Factor-Targeted Library
HY-L090
-
Protein-protein Interaction Inhibitor Library
HY-L109
-
Anti-Hematopathy Compound Library
HY-L171
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Covalent Screening Library Plus
HY-L036P
-
Bioactive Compound Library
HY-L001
-
Anti-Brain Cancer Compound Library
HY-L188
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
MDM2-p53-IN-16 (0.01 nM-100 μM; 1 hour) dissociates MDM2-p53 interaction with an IC50 value of 4.3 nM[1]. MDM2-p53-IN-16 (1 µM; 8 hours) significantly increases the levels of p53 in GBM cells[1]. MDM2-p53-IN-16 (1 µM; 6 hours) increases the mRNA levels of p53 target genes: MDM2, PUMA and p21 in U87MG cells[1]. MDM2-p53-IN-16 binds with translocator protein (TSPO) with a Ki value of 87.2 nM[1]. MDM2-p53-IN-16 (1 µM; 24 hours) induces early and late apoptosis and cell cycle arrest of U87MG cells[1]. MDM2-p53-IN-16 (1-10000 nM; 48 h) shows antiproliferative activities to U87MG and wild-type p53 U343MG cells with IC50 values of 1.2 and 1.6 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U87MG, U343MG and T98G cell lines
-
Concentration:1-10000 nM
-
Incubation Time:48 hours
-
Result:Inhibited cell proliferation of U87MG, U343MG and T98G cells.
-
Cell Line:U87MG cell line
-
Concentration:1 µM
-
Incubation Time:24 hours
-
Result:Induced cell apoptosis of U87MG cells.
-
Cell Line:U87MG, U343MG and T98G cell lines
-
Concentration:1-10000 nM
-
Incubation Time:48 hours
-
Result:Induced cell cycle arrest progression in the G2/M-phase of U87MG cells.
Chemical Information
-
CAS No. 1917350-09-4
-
Appearance Solid
-
Molecular Weight 539.62
-
Formula C32H33N3O5
-
Color Light green to green
-
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(OC)=O)=O)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (185.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (282 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8532 mL | 9.2658 mL | 18.5316 mL | 46.3289 mL |
| 5 mM | 0.3706 mL | 1.8532 mL | 3.7063 mL | 9.2658 mL | |
| 10 mM | 0.1853 mL | 0.9266 mL | 1.8532 mL | 4.6329 mL | |
| 15 mM | 0.1235 mL | 0.6177 mL | 1.2354 mL | 3.0886 mL | |
| 20 mM | 0.0927 mL | 0.4633 mL | 0.9266 mL | 2.3164 mL | |
| 25 mM | 0.0741 mL | 0.3706 mL | 0.7413 mL | 1.8532 mL | |
| 30 mM | 0.0618 mL | 0.3089 mL | 0.6177 mL | 1.5443 mL | |
| 40 mM | 0.0463 mL | 0.2316 mL | 0.4633 mL | 1.1582 mL | |
| 50 mM | 0.0371 mL | 0.1853 mL | 0.3706 mL | 0.9266 mL | |
| 60 mM | 0.0309 mL | 0.1544 mL | 0.3089 mL | 0.7721 mL | |
| 80 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5791 mL | |
| 100 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4633 mL |
MDM2-p53-IN-16 Related Classifications
HY-148833 Related Classifications
Powered by Bioz