VEGFR-2-IN-70
VEGFR-2-IN-70 is a potent VEGFR-2 inhibitor with an IC50 of 18.04 nM. VEGFR-2-IN-70 exhibits cytotoxicity against A549 and MCF-7 cancer cells with IC50 values of 0.43 μM and 3.8 μM, respectively. VEGFR-2-IN-70 induces G1 cell cycle arrest and apoptosis in lung cancer cells. VEGFR-2-IN-70 is useful in cancer research.
For research use only. We do not sell to patients.
- Formula: C20H17ClN6O2S
- Molecular Weight:440.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VEGFR2 18.04 nM (IC50) |
Bax |
Caspase-8 |
Caspase-9 |
Caspase 3 |
VEGFR-2-IN-70 (Compound 12g) (0.01-100 μM, 48 h) inhibits cell growth against A549 and MCF-7 cancer cells, with IC50s of 0.43 μM and 3.86 μM[1].
VEGFR-2-IN-70 (0.43 μM; 0-72 h) inhibits cell migration in A549 cells[1].
VEGFR-2-IN-70 (0.43 μM, 48 h) increases cell apoptosis, induces increased expression of pro-apoptotic genes and inhibits growth by causing cell cycle arrest at the G1 phase in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:0.43 μM
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Incubation Time:48 h
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Result:Increased apoptosis, resulting in an overall apoptotic cell death rate of 23.12% (including 19.21% early apoptosis and 3.91% late apoptosis) .
Caused a slight increase in necrotic cell death (4.84%).
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Cell Line:A549 cells
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Concentration:0.43 μM
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Incubation Time:48 h
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Result:Inhibited growth by causing cell cycle arrest at the G₁ phase, increased the percentage of cells in the G₁ phase to 76.53% and decreased the proportions of cells in the S phase and G₂/M phase to 19.36% and 4.11%, respectively.
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Cell Line:A549 cells
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Concentration:0.43 μM
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Incubation Time:48 h
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Result:Induced an increased in the expression of pro-apoptotic genes, such as P53 (fold change = 10.8), Bax (fold change = 8.7), and Caspase-3 (fold change = 9.6), Caspase-8 (fold change = 1.2), and Caspase-9 (fold change = 8.7) .
Suppressed the expression of anti-apoptotic genes Bcl-2 with 0.13-fold change.
Chemical Information
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Molecular Weight 440.91
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Formula C20H17ClN6O2S
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SMILES
CC1=C(C(NNC(NC2=C(C)N(C3=CC=C(Cl)C=C3)N=N2)=O)=O)SC4=C1C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-70 Related Classifications
HY-175019 Related Classifications
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