Apoptosis inducer 17
Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 3126845-21-1
- Formula: C25H27NO7
- Molecular Weight:453.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Apoptosis inducer 17 (compound CP; 0.027-60 μM; 72 h) inhibits cell proliferation, with IC50 values of 0.021 μM, 0.027 μM, and 0.73 μM for H446, H1299, and SBC-2 cells, respectively[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) displays superior inhibition of colony formation. Apoptosis inducer 17 induces dose-dependent G2/M arrest in H446 and H1299 cells[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) induces apoptosis of H446 and H1299 cells is mediated by caspase activity. And also activates JNK signaling cascade[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:H446, H1299, and SBC-2 cells
-
Concentration:60 μM, 20 μM, 6.67 μM, 2.22 μM, 0.74 μM, 0.25 μM, 0.082 μM, and 0.027 μM
-
Incubation Time:72 h
-
Result:Effectively inhibited cell proliferation.
-
Cell Line:H446, H1299 cells
-
Concentration:0.03 μM, 0.1 μM, 0.3 μM
-
Incubation Time:24 h
-
Result:Induced dose-dependent G2/M arrest.
-
Cell Line:H446, H1299 cells
-
Concentration:0.03 μM, 0.1 μM, 0.3 μM
-
Incubation Time:24 h
-
Result:Induced apoptosis of H446 and H1299 cells.
-
Cell Line:H446, H1299 cells
-
Concentration:0.03 μM, 0.1 μM, 0.3 μM
-
Incubation Time:24 h
-
Result:Led to a dose-dependent increase in the phosphorylation of JNK, c-Jun and activating transcription factor-2 (ATF-2) in both H446 and H1299 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice (4-6 weeks old) injected with H446 cells[1]
-
Dosage:10 mg/kg
-
Administration:ip; twice a day; for 15 days
-
Result:Prevented growth of lung cancer in xenograft tumors.
Chemical Information
-
CAS No. 3126845-21-1
-
Molecular Weight 453.48
-
Formula C25H27NO7
-
SMILES
O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC/C1=C\C3=CC=C(O)C(OC)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 17 Related Classifications
HY-163451 Related Classifications
Powered by Bioz