1. Protein Tyrosine Kinase/RTK
    MAPK/ERK Pathway
    Apoptosis
  2. FLT3
    MNK
    Apoptosis
  3. K783-0308

K783-0308 

Cat. No.: HY-115906
Handling Instructions

K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.

For research use only. We do not sell to patients.

K783-0308 Chemical Structure

K783-0308 Chemical Structure

CAS No. : 422554-29-8

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Description

K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase[1].

IC50 & Target

MNK2

406 nM (IC50)

In Vitro

K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells[1].
K783-0308 (1, 3, 10, 30 µM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 µg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 µg/mL))
Concentration: 1, 3, 10, 30 µM
Incubation Time: 48 h, 72 h
Result: Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.
Molecular Weight

333.43

Formula

C21H23N3O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
K783-0308
Cat. No.:
HY-115906
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