K783-0308
K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.
For research use only. We do not sell to patients.
- CAS No.: 422554-29-8
- Formula: C21H23N3O
- Molecular Weight:333.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
MNK2 406 nM (IC50) |
K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells[1].
K783-0308 (1, 3, 10, 30 µM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 µg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 µg/mL))
-
Concentration:1, 3, 10, 30 µM
-
Incubation Time:48 h, 72 h
-
Result:Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.
Chemical Information
-
CAS No. 422554-29-8
-
Molecular Weight 333.43
-
Formula C21H23N3O
-
SMILES
O=C(C1=CC=C2C(N=CN2C3=CC=C(CC)C=C3)=C1)NC4CCCC4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz