422554-29-8
422554-29-8
Chemical Structure
K783-0308
- CAS No.: 422554-29-8
- Formula:C21H23N3O
- Molecular Weight:333.43
IUPAC Name: N-cyclopentyl-1-(4-ethylphenyl)-1H-benzo[d]imidazole-5-carboxamide
InChIKey: YRPBJOATZCNOEP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(N=CN2C3=CC=C(CC)C=C3)=C1)NC4CCCC4
Biological Activity: K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase[1].
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K783-0308 | K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase. | |||||||||||||||||||||
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References
Keywords
